Author

S. Jacob

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Ecology· 2 Microbiology· 2 Biophysics· 1 Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

D. Legrand· 3 shared H. Philippe· 2 shared N. Schtickzelle· 2 shared A. Brunner· 1 shared A. C. Faber· 1 shared A. D. Junker· 1 shared A. Daigavane· 1 shared A. Duren-Lubanski· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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3 shared papersCell Biology

D. Legrand

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Author profile →

11 papers

Recent·Most cited

An array of signal-specific MoYpd1 isoforms determines full virulence in the pathogenic fungus Magnaporthe oryzae

S. Buhring, A. Brunner, K. Heeb, M.-P. Mergard, G. Schmauck, S. Jacob

This study identifies signal-specific MoYpd1 isoforms in Magnaporthe oryzae that are essential for virulence, showing their distinct roles in stress response and pathogenicity.

bioRxiv · Sep 21, 2023 · PreprintMicrobiology

Bacteriophage-mediated decolonization of Enterobacteriaceae in a novel Galleria mellonella gut colonization model

K. A. Mirza, S. Jacob, S. Nietzsche, O. Makarewicz, M. Pletz, L. Thieme

This study establishes a G. mellonella gut colonization model to compare phage and antibiotic efficacy in reducing Enterobacteriaceae colonization.

bioRxiv · Mar 27, 2023 · PreprintMicrobiology

A key regulator with a MIF-like domain orchestrates cellular differentiation and virulence in the fungal pathogen Magnaporthe oryzae

M. Galli, S. Jacob, Y. Zheng, P. Ghezellou, M. Gand, W. Albuquerque, J. Imani, V. Allasia, C. Coustau, B. Spengler, H. Keller, E. Thines, K.-H. Kogel

This study identifies MoMIF1, a MIF-like protein in Magnaporthe oryzae, as a key regulator of virulence by balancing biotrophy and necrotrophy during infection.

bioRxiv · Aug 5, 2022 · PreprintPlant Biology

Genomic screening reveals UBA1 as a potent and druggable target in c-MYC-high TNBC models

S. Jacob, T. H. Turner, J. Cai, K. V. Floros, A. K. Yu, C. M. Coon, R. Khatri, M. A. Alzubi, C. T. Jakubik, Y. M. Bouck, M. Puchalapalli, M. Shende, M. G. Dozmorov, S. Boikos, B. Hu, , A. C. Faber

The paper identifies UBA1 as a druggable target in c-MYC-high TNBC models, showing TAK-243 induces ER-stress and apoptosis in vitro and in vivo.

bioRxiv · May 17, 2022Cancer Biology

Retroviral Infection of Human Neurospheres and Use of Stem Cell EVs to Repair Cellular Damage

H. Branscome, P. Khatkar, S. Al Sharif, D. Yin, S. Jacob, M. Cowen, Y. Kim, J. Erickson, C. A. Brantner, N. El-Hage, L. A. Liotta, F. Kashanchi

This study uses iPSC-derived neurospheres to model HIV-1 infection and shows that stem cell EVs may repair cellular damage caused by HIV-1.

Scientific Reports · Feb 7, 2022Peer-reviewedCell Biology

Social information use for spatial decision in Zootoca vivipara

M. Brevet, S. Jacob, A. Rutschmann, M. Richard, J. Cote, J. Clobert

This study investigates how Zootoca vivipara use social information from multiple sources to make spatial movement decisions, finding that informant traits and environmental quality influence relocation choices.

bioRxiv · Oct 8, 2021Ecology

Plastic cell morphology changes during dispersal

A. D. Junker, S. Jacob, H. Philippe, D. Legrand, C. G. Pearson

The paper investigates morphological plasticity in dispersal strategies among Tetrahymena thermophila strains, finding that multiple plastic morphological changes influence cilia-dependent motility during dispersal.

bioRxiv · Jun 13, 2021Cell Biology

Dispersal syndromes affect ecosystem functioning in ciliate microcosms

A. Raffard, J. Campana, D. Legrand, N. Schtickzelle, S. Jacob

The paper tests how dispersal syndromes in ciliates affect ecosystem functioning by comparing biomass productivity of dispersers vs. residents across multiple genotypes.

bioRxiv · Feb 19, 2021 · PreprintEcology

Integrating deep learning and unbiased automated high-content screening to identify complex disease signatures in human fibroblasts

L. Schiff, B. Migliori, Y. Chen, D. Carter, C. Bonilla, J. Hall, M. Fan, E. Tam, S. Ahadi, B. Fischbacher, A. Geraschenko, C. J. Hunter, S. Venugopalan, S. DesMarteau, A. Narayanaswamy, , Yang

This study develops a platform combining deep learning and high-content imaging to identify disease-specific phenotypes in Parkinson's fibroblasts, achieving high accuracy in distinguishing disease subtypes.

bioRxiv · Nov 13, 2020Cell Biology

Transgenerational dispersal plasticity and its fitness consequences are under genetic control

H. Cayuela, S. Jacob, N. Schtickzelle, R. Verdonck, H. Philippe, M. Laporte, M. Huet, L. Bernatchez, D. Legrand

This study investigates how genotype influences transgenerational plasticity of dispersal traits across 200 clonal generations in ciliates, showing stable inheritance and genotype-dependent fitness effects.

bioRxiv · Oct 2, 2019 · PreprintEvolutionary Biology

Static length changes of cochlear outer hair cells can tune low-frequency hearing

N. Ciganovic, R. L. Warren, B. Keceli, S. Jacob, A. Fridberger, T. Reichenbach

The paper shows static length changes of outer hair cells can tune signal transmission to inner hair cells, enhancing low-frequency hearing sensitivity.

bioRxiv · Dec 3, 2017Biophysics