A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer
Q. Tian, P. Zhang, Y. Wang, Y. Si, D. Yin, C. R. Weber, M. Fishel, K. E. Pollok, B. Qiu, F. Xiao, A. Chong
This paper describes a novel triptolide analog, CK21, which downregulates the NF-κB pathway and induces mitochondrial apoptosis in human pancreatic cancer cells.
bioRxiv · Feb 15, 2023Pharmacology & Toxicology