CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses
S. Jalloh, J. Olejnik, J. Berrigan, A. Nisa, E. L. Suder, H. Akiyama, M. Lei, S. Tyagi, Y. Bushkin, E. Muhlberger, S. Gummuluru
This study shows CD169 enables ACE2-independent SARS-CoV-2 entry in macrophages, leading to restricted viral replication and pro-inflammatory cytokine production.
bioRxiv · Mar 29, 2022Immunology