S. Tyagi

Phosphoglucomutase A mediated regulation of carbon flux is essential for antibiotic and disease persistence in Mycobacterium tuberculosis

This study shows that phosphoglucomutase A (pgmA) is essential for Mycobacterium tuberculosis survival under nutrient-limiting conditions and disease persistence.

Contribution of telacebec to novel drug regimens in a murine tuberculosis model

This study evaluates telacebec's contribution to combination therapies against two M. tuberculosis strains in a murine model, finding synergistic effects against HN878 and antagonistic effects against H37Rv.

Direct inhibitors of InhA with efficacy similar or superior to isoniazid in novel drug regimens for tuberculosis

This study evaluates direct inhibitors of InhA (DIIs) for tuberculosis treatment, showing their efficacy comparable to isoniazid and their potential in new drug regimens.

VapC12 ribonuclease toxin modulates host immune response during Mycobacterium tuberculosis infection

This study shows that the VapC12 toxin in Mycobacterium tuberculosis modulates host immune responses, promoting pathogen survival by altering T-cell and neutrophil responses.

Hypothetical gene Rv0495c regulates redox homeostasis in Mycobacterium tuberculosis

This study identifies Rv0495c as a regulator of redox homeostasis in Mtb, showing that its absence increases ROS and susceptibility to stress, yet enhances pathogenicity in host models.

Metabolic alterations unravel the materno fetal immune responses with disease severity in pregnant women infected with SARS-CoV-2

This study examines metabolic and immune changes in pregnant women with SARS-CoV-2 infection, finding altered metabolic pathways and cytokine profiles associated with disease severity.

Interferon epsilon restricts Zika virus infection in the female reproductive tract

This study shows that IFNε protects against vaginal ZIKV infection in mice by maintaining epithelial integrity and is effective even without IFNAR1 signaling.

Rab7 dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis

This study shows Rab7 regulates CLCA1 in goblet cells, affecting mucus composition and gut microbiota, leading to increased susceptibility to colitis.

Imaging Architecture of Granulomas Induced by Mycobacterium tuberculosis Infections with Single-Molecule FISH

The paper develops a method to image mRNA and protein markers in tuberculosis granulomas using smFISH derivatives, enabling classification of immune cell subtypes and their spatial distribution.

Flavonols contrary affect the interconnected glucosinolate and camalexin biosynthesis pathway in Arabidopsis thaliana

This study investigates how flavonol deficiency and supplementation affect gene expression and metabolic pathways in Arabidopsis thaliana seedlings, revealing inverse regulation of camalexin and glucosinolate biosynthesis.

GSK2556286 is a novel antitubercular drug candidate effective in vivo with the potential to shorten tuberculosis treatment

MLL family members regulate H3K4 methylation to ensure CENP-A assembly at human centromeres.

This study shows that MLL family members methylate H3K4 to regulate centromere epigenetic state and kinetochore maintenance.

CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses

This study shows CD169 enables ACE2-independent SARS-CoV-2 entry in macrophages, leading to restricted viral replication and pro-inflammatory cytokine production.

Glutamine is required for M1-like polarization in response to Mycobacterium tuberculosis infection

This study identifies glutamine as essential for M1-like macrophage polarization during Mycobacterium tuberculosis infection through metabolic reprogramming involving the TCA cycle and biosynthesis of signaling molecules and antimicrobial metabolites.

The heterogeneity of the DNA damage response landscape determines patient outcomes in ovarian cancer

The paper shows that DDR heterogeneity in ovarian cancer predicts patient outcomes and chemotherapy response by analyzing DDR pathway interactions and constructing predictive DDR signatures.

Telacebec for ultra-short treatment of Buruli ulcer in a mouse model

This study evaluates Telacebec's efficacy in shortening Buruli ulcer treatment in mice, showing it can cure infections in as little as 1 week with no relapse.

Aging of human endocrine pancreatic cell types is heterogeneous and sex-specific

This study analyzes age-related changes in human endocrine pancreatic cell types, finding sex-specific and cell-type-specific effects of aging on beta cell function and transcriptional profiles.

Activity of a long-acting injectable bedaquiline formulation in a paucibacillary mouse model of latent tuberculosis infection

This study evaluates a long-acting injectable bedaquiline formulation in a mouse model of latent tuberculosis, showing its efficacy with fewer doses compared to daily oral regimens.