c-Myc plays a key role in IFN-γ induced persistence of Chlamydia trachomatis
N. Vollmuth, S. Janaki-Raman, L. Schlicker, N. Kurmasheva, W. Schmitz, A. Schulze, T. Rudel, K. Rajeeve
This study shows that IFN-γ induces Chlamydia persistence by depleting c-Myc, which is regulated by the PI3K-GSK3β axis and L-tryptophan levels, challenging the IDO depletion hypothesis.
bioRxiv · Mar 9, 2021Microbiology