S. K. Sarin

Epigenetic mediated functional reprogramming of immune cells leads to HBsAg seroconversion in Hepatitis B Virus Reactivation patients

This study identifies epigenetic changes in HBV reactivation patients that drive immune and metabolic reprogramming, leading to HBsAg seroconversion.

Hepatitis B virus x (HBx) protein increases cellular OCT3/4 and MYC and facilitates cellular reprogramming (of fibroblasts to iPSC)

This study shows HBx enhances reprogramming efficiency of fibroblasts to iPSC by increasing OCT3/4 and MYC levels, and can substitute MYC in the Yamanakas factor cocktail.

Metabolic alterations unravel the materno fetal immune responses with disease severity in pregnant women infected with SARS-CoV-2

This study examines metabolic and immune changes in pregnant women with SARS-CoV-2 infection, finding altered metabolic pathways and cytokine profiles associated with disease severity.

Genomic perspectives of SARS CoV-2 in liver disease patients with its clinical correlation: A single centre retrospective study

This study compares the mutational and clinical profiles of liver disease patients infected with different SARS CoV-2 variants, finding higher mortality risk and specific genetic mutations associated with adverse outcomes.

Cloning of Human ABCB11 Gene in E. coli required the removal of an Intragenic Pribnow-Schaller Box before its Insertion into Genomic Safe Harbor AAVS1 Site using CRISPR Cas9

The paper inserts the human ABCB11 gene into the AAVS1 site in HEK 293T cells using CRISPR-Cas9, but reports low homologous recombination efficiency.