R. Agarwal

Nuclear envelope rupture in cardiomyocytes orchestrates early transcriptomic changes and immune activation in LMNA-related dilated cardiomyopathy that are reversed by LINC complex disruption

This study identifies NE rupture in LMNA-DCM cardiomyocytes as a driver of transcriptomic changes and immune activation, which can be reversed by LINC complex disruption.

Chikungunya-virus-specific CD4+ T cells are associated with chronic chikungunya viral arthritic disease in humans

This study identifies CHIKV-specific CD4+ T cell responses in chronic CHIKVD patients, showing stronger responses and Th17 enrichment compared to resolved infection.

Behavioral adaptation to changing energy constraints via altered frequency of movement selection

The paper shows larval zebrafish adjust movement frequency to minimize energy use as they grow, even in altered fluid environments.

Partnership with both fungi and bacteria can protect Odontotermes obesus fungus gardens against fungal invaders.

This study identifies pathogenic fungi in termite fungus gardens and shows that interactions with bacteria and the crop fungus help maintain a Termitomyces monoculture.

Pose prediction accuracy in ligand docking to RNA

This study evaluates pose prediction accuracy of docking protocols for RNA-small molecule complexes, finding rDock slightly better than Vina for known structures but both underperform compared to protein targets.

Genomic perspectives of SARS CoV-2 in liver disease patients with its clinical correlation: A single centre retrospective study

This study compares the mutational and clinical profiles of liver disease patients infected with different SARS CoV-2 variants, finding higher mortality risk and specific genetic mutations associated with adverse outcomes.

Lung-mimicking 3-Dimensional hydrogel culture system recapitulates key tuberculosis phenotypes and demonstrates pyrazinamide efficacy

This paper develops a 3D hydrogel culture system that mimics lung tissue and reproduces key tuberculosis phenotypes, demonstrating the efficacy of pyrazinamide.

Sustained release Resolvin D1 liposomes are effective in the treatment of osteoarthritis in obese mice

This study shows that liposomal Resolvin D1 reduces cartilage damage in obese mice with osteoarthritis by increasing anti-inflammatory macrophages.

Differential Boric Acid and Water Transport in Type I and Type II Pores of Arabidopsis Nodulin 26-Intrinsic Protein

This study compares boric acid and water transport in Arabidopsis NIP I and II proteins, showing differences linked to the ar/R filter's helix 2 amino acid.

Host specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome

This study identifies CARD8 as a sensor for viral proteases, showing it activates inflammasomes in response to coronavirus 3CLpro and can be modulated by genetic variation.

Immunomodulatory effect of mycobacterial outer membrane vesicles coated nanoparticles

This study develops OMV-AuNP as a stabilized TB vaccine candidate showing enhanced immune activation through TLR2 and TLR4.

Structure-based identification of novel histone deacetylase 4 (HDAC4) inhibitors

The paper identifies novel HDAC4 inhibitors using molecular modeling and in vivo testing, finding compounds that selectively target HDAC4 over other HDAC classes.

Distribution and frequency of salivary gland tumours: an international multicenter study

This study analyzes global salivary gland tumor data from 15 centers to provide updated epidemiological insights on incidence, demographics, and tumor types.

A natural broad-spectrum inhibitor of enveloped virus entry, effective against SARS-CoV-2 and Influenza A Virus in preclinical animal models.

This paper identifies picolinic acid as a broad-spectrum antiviral that inhibits enveloped virus entry, showing efficacy against SARS-CoV-2 and Influenza A Virus in animal models.

Genomic and phenotypic analyses suggest moderate fitness differences among Zika virus lineages

The paper analyzes genomic and phenotypic data from Zika virus lineages to assess fitness differences during the 2015-2016 epidemic, finding moderate fitness changes but no significant virulence or transmission enhancement.

Cationic inhalable particles for enhanced drug delivery to M. tuberculosis infected macrophages

This study shows cationic inhalable microparticles enhance drug delivery to Mtb-infected macrophages, improving anti-bacterial function and uptake in vitro and in mice lungs.

Mars, a molecule archive suite for reproducible analysis and reporting of single molecule properties from bioimages

Mars is an open-source platform for analyzing and reporting single-molecule properties from bioimages, offering tools for tracking, fluorescence imaging, and force spectroscopy.

Rapamycin microparticles induce autophagy, prevent senescence and are effective in treatment of Osteoarthritis

This study develops rapamycin-loaded microparticles that induce autophagy, prevent senescence, and reduce OA symptoms in mice.

Pseudomonas can prevent the parasitic fungus, while keeping the crop fungus unaffected, in the gardens of Odontotermes obesus.

This study identifies Pseudomonas as a defensive mutualist in fungus-growing termites that suppresses parasitic fungi without affecting the crop fungus.

Iron acquisition across outer membrane: The role of major outer membrane protein Slr1908 under iron supplemented conditions in Synechocystis 6803

This study investigates the role of Slr1908 in iron acquisition under iron-supplemented conditions in Synechocystis 6803, showing its importance in iron uptake and the compensatory upregulation of other transporters.

Diverse viral proteases activate the NLRP1 inflammasome

This study identifies viral proteases from picornaviruses that activate human NLRP1 inflammasome through specific cleavage, revealing a host-specific immune response mechanism.

Mesophilic enzyme function at high temperature: moleculardynamics of hyperthermophilic and mesophilicpyrophosphatases

This study compares the molecular dynamics of mesophilic and hyperthermophilic pyrophosphatases to explain their differing thermal stability and function.

Antimycobacterial potential of Mycobacteriophage under disease-mimicking conditions

This study evaluates the effectiveness of mycobacteriophages against Mycobacteria under disease-mimicking conditions and shows their ability to prevent resistance and synergize with antibiotics.

Rapamycin-PLGA microspheres induce autophagy and prevent senescence in chondrocytes and exhibit long in vivo residence

This paper develops rapamycin-loaded PLGA microspheres that induce autophagy and prevent chondrocyte senescence, showing sustained drug release and prolonged joint residence in mice.

Structure based virtual screening identifies novel competitive inhibitors for the sialoglycan binding protein Hsa

The paper identifies nine novel competitive inhibitors of the sialoglycan binding protein Hsa using structure-based virtual screening and in vitro validation.

Selectivity and engineering of the sialoglycan-binding spectrum in Siglec-like adhesins

This study identifies determinants of sialoglycan-binding selectivity in Siglec-like adhesins and creates engineered binding proteins for specific glycan recognition.