S. Karumuthil-Melethil

Activation of T cell checkpoint pathways during beta-cell antigen presentation by engineered dendritic cells promotes protection of non-obese diabetic mice from type 1 diabetes

Engineered dendritic cells expressing checkpoint receptor ligands reduce insulitis and hyperglycemia in NOD mice by enhancing regulatory T cell responses and suppressing effector T cell function.

Engineered Dendritic Cell-Directed Concurrent Activation of Multiple T cell Inhibitory Pathways Induces Robust Immune Tolerance

This study shows engineered dendritic cells expressing multiple T cell inhibitory ligands induce CD4+ T cell tolerance and suppress autoimmunity.

Complex dietary-polysaccharide modulates gut immune function and microbiota, and promotes protection from autoimmune diabetes

This study shows that oral administration of yeast β-glucan modulates gut immune function, microbiota, and delays type 1 diabetes in NOD mice.