C. Vasu

Fecal immunoglobulin A (IgA) and its subclasses in systemic lupus erythematosus patients are nuclear antigen reactive and this feature correlates with gut permeability marker levels

This study shows that fecal IgA and its subclasses in SLE patients are reactive to nuclear antigens and correlate with gut permeability markers.

Preclinical stage abundance and nuclear antigen reactivity of fecal Immunoglobulin A (IgA) varies among males and females of lupus-prone mouse models

The paper examines fecal IgA abundance and nuclear antigen reactivity in lupus-prone mouse models, finding gender and model-specific variations that correlate with future autoantibody levels.

Activation of T cell checkpoint pathways during beta-cell antigen presentation by engineered dendritic cells promotes protection of non-obese diabetic mice from type 1 diabetes

Engineered dendritic cells expressing checkpoint receptor ligands reduce insulitis and hyperglycemia in NOD mice by enhancing regulatory T cell responses and suppressing effector T cell function.

Gastrin producing syngeneic mesenchymal stem cells protect non-obese diabetic mice from type 1 diabetes

This study shows that Gastrin-producing mesenchymal stem cells protect NOD mice from type 1 diabetes by preserving beta-cell mass and modulating immune responses.

Loss of CPAP expression promotes sustained EGFR signaling and Epithelial-Mesenchymal Transition in oral cancer cells

This study shows that loss of CPAP increases EGFR signaling and promotes EMT and invasiveness in OSCC cells, which can be reversed by EGFR depletion.

Centrosomal P4.1-associated protein (CPAP) positively regulates endocytic vesicular transport and lysosome targeting of EGFR

This study shows CPAP promotes endocytic transport and lysosome targeting of EGFR by facilitating its movement from early to late endosomes and MVBs.

Abundance and nuclear antigen reactivity of intestinal and fecal Immunoglobulin A in lupus-prone mice at younger ages correlate with the onset of eventual systemic autoimmunity

The paper examines IgA abundance and nuclear antigen reactivity in intestinal and fecal samples of lupus-prone mice, finding correlations with systemic autoimmunity onset.

Gut microbiota differently contributes to intestinal immune phenotype and systemic autoimmune progression in female and male lupus-prone mice

This study shows that gut microbiota influences intestinal immune responses and autoimmune progression differently in male and female lupus-prone mice, with gender-specific effects on disease susceptibility.

Pretreatment with yeast derived complex dietary-polysaccharide leads to suppressed gut inflammation, altered microbiota composition and increased immune regulatory short-chain fatty acid production in C57BL/6 mice

This study shows that pretreatment with yeast-derived beta-glucans reduces DSS-induced colitis in mice by altering gut microbiota and increasing SCFA production, but loses efficacy when administered during disease onset.

Engineered Dendritic Cell-Directed Concurrent Activation of Multiple T cell Inhibitory Pathways Induces Robust Immune Tolerance

This study shows engineered dendritic cells expressing multiple T cell inhibitory ligands induce CD4+ T cell tolerance and suppress autoimmunity.

Polysaccharide A-dependent opposing effects of mucosal and systemic exposures to human gut commensal Bacteroides fragilis in type 1 diabetes

This study shows that mucosal and systemic exposures to Bacteroides fragilis have opposing effects on type 1 diabetes in NOD mice, with polysaccharide-A playing a key role.

Complex dietary-polysaccharide modulates gut immune function and microbiota, and promotes protection from autoimmune diabetes

This study shows that oral administration of yeast β-glucan modulates gut immune function, microbiota, and delays type 1 diabetes in NOD mice.