Disulfiram inhibits M. tuberculosis growth by altering methionine pool, redox status and host-immune response
D. Chaudhary, M. Marzuki, A. Lee, R. Bouzeyen, A. Singh, T. P. Gosain, S. Kidwai, C. Grady, K. Tsotetsi, K. Chawla, F. Shihui, J. Lum, S. K. Gupta, N. Agarwal, L. Tsenova, , A. Singhal
This study identifies disulfiram as a novel inhibitor of Mtb's methionine biosynthesis, showing anti-tubercular effects through redox disruption and immune modulation.
bioRxiv · Sep 1, 2020 · PreprintMicrobiology