N. R. Casewell

Dermonecrosis caused by spitting cobra snakebite results from toxin potentiation and is prevented by the repurposed drug varespladib

This study identifies toxin synergism in spitting cobra venom causing dermonecrosis and shows that varespladib prevents tissue damage in mouse models.

Machine-learning guided Venom Induced Dermonecrosis Analysis tooL: VIDAL

VIDAL is a machine-learning tool that automatically analyzes dermonecrosis in mouse models to assess antivenom efficacy, offering an accurate and reproducible alternative to manual methods.

An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules

This paper develops an in vitro assay to screen for venom neurotoxin activity on muscle-type nAChR and identify toxin-inhibitory molecules, showing robust assay performance across 96-well plates.

Exploring the utility of ssDNA aptamers directed against snake venom toxins as new therapeutics for tropical snakebite envenoming

This study identifies ssDNA aptamers that inhibit snake venom toxins and show comparable efficacy to antivenoms in vitro and ex vivo.

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms

The paper shows repurposed drugs and their combinations reduce cytotoxicity of snake venoms in cell and mouse models, offering potential new treatments for snakebite envenoming.

Two snakebite antivenoms have potential to reduce Eswatini's dependency upon a single, increasingly unavailable product: results of preclinical efficacy testing

This study evaluates two antivenoms as alternatives to SAIMR Polyvalent in Eswatini, finding they are equally or more effective against the most common snake venom but less effective against others.

Exploring the utility of recombinantly expressed snake venom serine protease toxins as immunogens for generating experimental snakebite antivenoms

This study evaluates recombinant snake venom serine protease toxins as immunogens to generate antivenoms that target specific venom-induced pathologies.

Spatial Venomics - Cobra Venom System Reveals Spatial Differentiation of Snake Toxins by Mass Spectrometry Imaging

This study uses MALDI-MSI to map toxin distribution in Egyptian cobra venom glands, revealing spatial heterogeneity at the proteoform level.

In vitro and in vivo venom-inhibition assays identify metalloproteinase-inhibiting drugs as potential treatments for snakebite envenoming by Dispholidus typus

This study evaluates four SVMP inhibitors for treating D. typus snakebite envenoming, finding DMPS and marimastat effective in preclinical models.

Convergent Evolution of Pain-Inducing Defensive Venom Components in Spitting Cobras

This study shows that three spitting cobra lineages independently evolved venom with increased pain-enhancing toxins, likely in response to hominin emergence.

Neutralizing effects of small molecule inhibitors and metal chelators on coagulopathic Viperinae snake venom toxins

This study investigates the neutralizing effects of small molecule inhibitors and metal chelators on coagulopathic toxins in Viperinae snake venoms using chromatography, mass spectrometry, and bioassaying.

A combination of two small molecule toxin inhibitors provides pancontinental preclinical efficacy against viper snakebite

This study shows that a combination of two small molecule inhibitors effectively neutralizes viper venom in vitro and prevents lethality in vivo across multiple regions.

Development of high-throughput screening assays for profiling snake venom Phospholipase A2 activity after high resolution chromatographic fractionation

The paper develops high-throughput assays to profile PLA2 activity in snake venoms after chromatographic fractionation, using absorbance and fluorescence detection methods.

Evaluation of the geographical utility of Eastern Russells viper (Daboia siamensis) antivenom from Thailand and an assessment of its protective effects against venom-induced nephrotoxicity

This study evaluates the effectiveness of Thai-made D. siamensis antivenom against venoms from Myanmar, Taiwan, and Thailand, showing it can neutralize coagulopathy and nephrotoxicity but requires high doses early for efficacy.

Preclinical validation of a repurposed metal chelator as a community-based therapeutic for hemotoxic snakebite

This paper shows that the metal chelator DMPS can effectively treat hemotoxic snakebite in mice, both when given orally and in combination with antivenom.

Community venomics reveals intra-species variations in venom composition of a local population of Vipera kaznakovi in Northeastern Turkey

This study analyzes venom composition variation in Vipera kaznakovi from Northeastern Turkey, finding age-related differences driven by small molecular weight toxins and PLA2s.