Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis
C. Maserumule, C. Passemar, O. Oh, K. Hegyi, K. Brown, A. Weimann, A. Dinan, S. Davila, C. Klapholz, J. Bryant, D. Verma, J. Gadwa, S. Krishnananthasivam, K. Vongtongsalee, E. Kendall, , R. A. Floto
The paper identifies TLR8 as a key regulator of intracellular killing of Mtb, showing that phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis and reveals a druggable pathway for host-directed therapy.
bioRxiv · Jun 14, 2022Immunology