Author

R. A. Floto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Research Focus:drug response / drug discovery· 3 Organism:bacteria (other)· 2 Assay:bulk RNA-seq· 2 Approach:deep learning· 2 Organism:human· 2 Approach:statistical model· 2

Frequent Co-Authors

A. Weimann· 3 shared A. M. Dinan· 2 shared C. Ruis· 2 shared J. Parkhill· 2 shared K. Brown· 2 shared T. L. Blundell· 2 shared A. Alsulami· 1 shared A. Bernut· 1 shared

Activity by Year

2019-2024 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

A. Weimann

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Sequence-based modelling of bacterial genomes enables accurate antibiotic resistance prediction

M. Wiatrak, A. Weimann, A. M. Dinan, M. Brbic, R. A. Floto

This study introduces GeneBac, a deep learning model that predicts antibiotic resistance from bacterial genomic sequences, showing accurate MIC prediction and variant effect assessment.

bioRxiv · Jan 3, 2024 · PreprintMicrobiology

Epigenetic and transcriptional plasticity drive inflammation in Cystic Fibrosis

A. M. Dinan, O. Eneje, K. P. Brown, F. Burden, M. Morse, R. Prinjha, M. Frontini, R. A. Floto

The paper links acute pulmonary exacerbations in Cystic Fibrosis to immune signaling and epigenetic changes, showing antibiotic treatment reverses these effects.

bioRxiv · Oct 12, 2022 · PreprintImmunology

Mutational spectra distinguish SARS-CoV-2 replication niches

C. Ruis, T. P. Peacock, L. M. Polo, D. Masone, M. Soledad Alvarez, A. S. Hinrichs, Y. Turakhia, C. Ye, J. McBroome, R. Corbett-Detig, J. Parkhill, R. A. Floto

The paper analyzes SARS-CoV-2 mutational spectra to infer replication niches, finding reduced G>T mutations in Omicron linked to upper respiratory tract replication.

bioRxiv · Sep 27, 2022 · PreprintMicrobiology

Mutational spectra analysis reveals bacterial niche and transmission routes

C. Ruis, A. Weimann, G. Tonkin-Hill, A. P. Pandurangan, M. MATUSZEWSKA, G. G. R. Murray, R. C. Levesque, T. L. Blundell, R. A. Floto, J. Parkhill

The paper analyzes mutational spectra in bacterial lineages to infer niche-specific mutagen exposure and transmission routes.

bioRxiv · Jul 13, 2022 · PreprintMicrobiology

Ionic control of porin permeability in bacteria.

S. Cano Muniz, A. Hagting, I. Evans, A. Alsulami, D. K. Summers, T. Blundell, R. A. Floto

The paper shows bacterial porin permeability is regulated by periplasmic pH and potassium levels, affecting antibiotic resistance.

bioRxiv · Jul 13, 2022 · PreprintMicrobiology

Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis

C. Maserumule, C. Passemar, O. Oh, K. Hegyi, K. Brown, A. Weimann, A. Dinan, S. Davila, C. Klapholz, J. Bryant, D. Verma, J. Gadwa, S. Krishnananthasivam, K. Vongtongsalee, E. Kendall, , R. A. Floto

The paper identifies TLR8 as a key regulator of intracellular killing of Mtb, showing that phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis and reveals a druggable pathway for host-directed therapy.

bioRxiv · Jun 14, 2022Immunology

Deletion of cftr leads to an excessive neutrophilic response and defective tissue repair in a zebrafish model of sterile inflammation

A. Bernut, C. A. Loynes, R. A. Floto, S. A. Renshaw

This study shows that CFTR deletion in zebrafish causes excessive neutrophilic inflammation and impaired tissue repair, which can be mitigated by Tanshinone IIA.

bioRxiv · Nov 14, 2019Immunology

Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification

S. E. Thomas, A. J. Whitehouse, K. Brown, J. M. Belardinelli, R. Lahiri, M. D. J. Libardo, P. Gupta, S. Malhotra, H. I. M. Boshoff, M. Jackson, C. Abell, A. G. Coyne, T. L. Blundell, R. A. Floto, V. Mendes

This study identifies new TrmD inhibitors for mycobacterial infections using fragment-based drug discovery, showing activity against multiple mycobacterial species in vitro and in macrophage models.

bioRxiv · May 19, 2019Biochemistry