J. Bryant

Machine learning prediction of cancer cell metabolism from autofluorescence lifetime images

This paper uses machine learning on autofluorescence lifetime images to predict metabolic pathway usage in cancer cells, achieving 95% accuracy in distinguishing glycolytic and oxidative metabolism.

Phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis

The paper identifies TLR8 as a key regulator of intracellular killing of Mtb, showing that phagosomal RNA sensing through TLR8 controls susceptibility to tuberculosis and reveals a druggable pathway for host-directed therapy.

A genetic screen to identify factors affected by undecaprenyl phosphate recycling uncovers novel connections to morphogenesis in Escherichia coli

The paper identifies novel factors affecting morphogenesis in E. coli by screening for synthetic mutations in Und-P metabolism.

The common analgesic paracetamol enhances the anti-tumour activity of decitabine through exacerbation of oxidative stress

This study shows that paracetamol enhances decitabine's anti-tumour effects by increasing oxidative stress without worsening DNA damage.

Structure-function analysis of the Escherichia coli β-barrel assembly enhancing protease BepA suggests a role for a self-inhibitory state

This study presents the crystal structure of BepA, a protease involved in LptD folding, and shows its auto-regulation and role in maintaining outer membrane lipid asymmetry.

Preadaptation of pandemic GII.4 noroviruses in hidden virus reservoirs years before emergence

This paper shows that GII.4 noroviruses preadapt and circulate undetected for years before causing a new pandemic, with changes in host immunity enabling spread rather than genetic changes alone.

MCE domain proteins: conserved inner membrane lipid-binding proteins required for outer membrane homeostasis

The paper identifies and characterizes MCE domain proteins in E. coli, showing they localize to the inner membrane and play distinct roles in maintaining outer membrane lipid asymmetry.