Author

M. P. Soares

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Evolutionary Biology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

R. Martins· 3 shared S. Cardoso· 3 shared E. Jentho· 2 shared J. Guerra· 2 shared Q. Wu· 2 shared S. Ramos· 2 shared S. Weis· 2 shared T. W. Ademolue· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersImmunology

R. Martins

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Theft of Host Transferrin Receptor-1 by Toxoplasma gondii is required for infection

S. L. Denton, A. Mejia, L. L. Nevarez, M. P. Soares, B. A. Fox, D. J. Bzik, J. P. Gigley

This study shows Toxoplasma gondii steals host transferrin receptor 1 and transferrin to enhance growth, but not iron levels.

bioRxiv · Jun 23, 2023 · PreprintMicrobiology

A Protective Inter-Organ Communication Response Against Life-Threatening Malarial Anemia

Q. Wu, E. Sacomboio, L. V. Souza, R. Martins, S. Cardoso, T. W. Ademolue, T. Paixao, J. Lehtimaki, C. Norden, P.-L. Tharaux, G. Weiss, F. Wang, S. Ramos, M. P. Soares

The paper shows that kidney cells reprogram iron metabolism to prevent severe malarial anemia by supporting erythropoiesis.

bioRxiv · Jan 12, 2022Pathology

A HYPOMETABOLIC DEFENSE STRATEGY AGAINST PLASMODIUM INFECTION

S. Ramos, T. W. Ademolue, E. Jentho, Q. Wu, J. Guerra, R. Martins, G. Pires, S. Weis, A. R. Carlos, I. Mahu, E. Seixas, D. Duarte, F. Rajas, S. Cardoso, A. G. Sousa, , M. P. Soares

The paper shows that Plasmodium infection induces hypoglycemia in mice through heme-driven suppression of hepatic glucose production, which limits parasite growth but promotes gametocyte production.

bioRxiv · Sep 8, 2021Immunology

Glycan-Based Shaping Of The Microbiota During Primate Evolution

S. Singh, P. Bastos-Amador, J. A. Thompson, M. Truglio, B. Yilmaz, S. Cardoso, D. Sobral, M. P. Soares

The paper investigates how loss of GGTA1 function in primates affects host-microbiota interactions, finding that it reduces microbiota pathogenicity through IgA targeting of Gal-expressing bacteria.

bioRxiv · Feb 10, 2021Evolutionary Biology

Heme induces innate immunity memory

E. Jentho, B. Novakovic, C. C. Ruiz-Moreno, I. Kourtzelis, R. Martins, T. Chavakis, M. P. Soares, L. Kalafati, J. Guerra, F. Roestel, P. Bohm, M. Godmann, T. Grinenko, A. Eugster, M. Beretta, , S. Weis

This study shows heme induces trained immunity in human and murine cells, leading to long-term protection against bacterial sepsis through epigenetic and transcriptional changes.

bioRxiv · Dec 12, 2019 · PreprintImmunology