Author

S. L. Yuen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

D. D. Thomas· 2 shared R. L. Cornea· 2 shared A. Li· 1 shared A. R. Thompson· 1 shared C. C. Aldrich· 1 shared D. R. Stroik· 1 shared E. Kleinboehl· 1 shared L. N. Roelike· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiophysics

D. D. Thomas

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2 papers

Recent·Most cited

FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators

O. Roopnarine, S. L. Yuen, A. R. Thompson, L. N. Roelike, R. T. Rebbeck, P. A. Bidwell, C. C. Aldrich, R. L. Cornea, D. D. Thomas

The paper uses a FRET assay to screen compounds affecting the cardiac SERCA pump, identifying activators and inhibitors with potential therapeutic applications for heart failure.

bioRxiv · Feb 22, 2023 · PreprintBiophysics

The transmembrane domain of DWORF activates SERCA directly; P15 and W22 residues are essential.

A. Li, D. R. Stroik, S. L. Yuen, E. Kleinboehl, R. L. Cornea, D. D. Thomas

This study identifies key residues in DWORF that activate SERCA2a by displacing PLB, using FRET biosensors and mutagenesis.

bioRxiv · Sep 18, 2020 · PreprintBiophysics