Author

C. C. Aldrich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Assay:fluorescence / live-cell microscopy· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

D. D. Thomas· 2 shared R. L. Cornea· 2 shared R. T. Rebbeck· 2 shared A. A. Bauman· 1 shared A. D. Baughn· 1 shared A. Muir· 1 shared A. R. Thompson· 1 shared B. Svensson· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersBiophysics

D. D. Thomas

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

FRET assay for live-cell high-throughput screening of the cardiac SERCA pump yields multiple classes of small-molecule allosteric modulators

O. Roopnarine, S. L. Yuen, A. R. Thompson, L. N. Roelike, R. T. Rebbeck, P. A. Bidwell, C. C. Aldrich, R. L. Cornea, D. D. Thomas

The paper uses a FRET assay to screen compounds affecting the cardiac SERCA pump, identifying activators and inhibitors with potential therapeutic applications for heart failure.

bioRxiv · Feb 22, 2023 · PreprintBiophysics

Cell envelope remodeling requires high concentrations of biotin during Mycobacterium abscessus model lung infection

M. R. Sullivan, K. McGowen, Q. Liu, C. Akusobi, D. C. Young, J. A. Mayfield, S. Raman, I. D. Wolf, D. B. Moody, C. C. Aldrich, A. Muir, E. J. Rubin

This study identifies biotin-dependent fatty acid remodeling as essential for Mycobacterium abscessus survival in the lung, suggesting biotin synthesis and fatty acid metabolism as therapeutic targets.

bioRxiv · Jul 20, 2022 · PreprintMicrobiology

Parameterization and Application of the General Amber Force Field to Model Fluro Substituted Furanose Moieties and Nucleosides

D. E. Escalante, C. C. Aldrich, D. M. Ferguson

The paper refines torsional parameters in the General Amber Force Field to better model fluorinated furanose rings and nucleosides using quantum mechanics and experimental validation.

bioRxiv · Jan 26, 2022 · PreprintBiophysics

Cardiac RyR N-terminal region biosensors for FRET-based high-throughput screening

J. Zhang, S. M. W. K. Yuen, J. A. Schwarz, L. M. Treinen, C.-C. Tung, R. T. Rebbeck, K. Ro?man, B. Svensson, C. C. Aldrich, D. D. Thomas, F. Van Petegem, R. L. Cornea

This study develops FRET-based biosensors to screen for RyR modulators, identifying novel inhibitors and activators with therapeutic potential.

bioRxiv · Feb 7, 2021 · PreprintBiophysics

Methionine antagonizes para-aminosalicylic acid activity via affecting folate precursor biosynthesis pathway in Mycobacterium tuberculosis

M. D. Howe, S. L. Kordus, M. S. Cole, A. A. Bauman, C. C. Aldrich, A. D. Baughn, Y. Minato

This study identifies methionine's role in antagonizing PAS activity by affecting folate precursor biosynthesis in M. tuberculosis.

bioRxiv · May 17, 2018Microbiology