Author

E. Kleinboehl

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Approach:microscopy & imaging analysis· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. Li· 1 shared B. J. Wick· 1 shared B. R. Webber· 1 shared B. S. Moriarity· 1 shared D. D. Thomas· 1 shared D. R. Stroik· 1 shared J. D. Jensen· 1 shared J. J. Peterson· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

A. Li

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Engineering Memory T Cells as a platform for Long-Term Enzyme Replacement Therapy in Lysosomal Storage Disorders

E. Kleinboehl, K. Laoharawee, J. D. Jensen, J. J. Peterson, N. J. Slipek, B. J. Wick, M. J. Johnson, B. R. Webber, B. S. Moriarity

This study demonstrates that genetically engineered memory T cells can deliver enzyme replacement therapy for mucopolysaccharidosis type I, reducing GAG levels in multiple tissues for up to 22 weeks.

bioRxiv · Apr 23, 2024 · PreprintBioengineering

The transmembrane domain of DWORF activates SERCA directly; P15 and W22 residues are essential.

A. Li, D. R. Stroik, S. L. Yuen, E. Kleinboehl, R. L. Cornea, D. D. Thomas

This study identifies key residues in DWORF that activate SERCA2a by displacing PLB, using FRET biosensors and mutagenesis.

bioRxiv · Sep 18, 2020 · PreprintBiophysics