Author

G. Talaia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 5 Approach:experimental assay· 5 Organism:human· 2 Assay:proteomics· 2 Research Focus:differential expression· 1 Assay:imaging· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

S. Ferguson· 3 shared J. Amick· 2 shared A. Bentley-DeSousa· 1 shared A. Haberman· 1 shared A. K. Tharkeshwar· 1 shared C. Barata Antunes· 1 shared C. J. Stefan· 1 shared D. Athonvarangkul· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersCell Biology

S. Ferguson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Lysosomal TBK1 Responds to Amino Acid Availability to Relieve Rab7-Dependent mTORC1 Inhibition

G. Talaia, A. Bentley-DeSousa, S. Ferguson

The paper identifies TBK1's role in lysosomal signaling, showing it phosphorylates Rab7 to relieve mTORC1 inhibition in response to amino acids.

bioRxiv · Dec 16, 2023Cell Biology

Intracellular Calcium links Milk Stasis to Lysosome Dependent Cell Death by Activating a TGFbeta3/TFEB/STAT3 Pathway Early during Mammary Gland Involution

J. JEONG, J. Lee, G. Talaia, W. Kim, J. Song, J. Hong, K. Yoo, D. Gonzalez, D. Athonvarangkul, J. Shin, P. Dann, A. Haberman, L. K. Kim, S. Ferguson, J. Choi, J. Wysolmerski

The paper shows that intracellular calcium, triggered by milk stasis, activates STAT3 via SOCS3 degradation and TFEB, leading to lysosome-dependent cell death during mammary gland involution.

bioRxiv · May 17, 2022 · PreprintCell Biology

Interactions of cytosolic termini of the Jen1 monocarboxylate transporter are critical for trafficking, transport activity and endocytosis

C. Barata Antunes, G. Talaia, G. Broutzakis, D. Ribas, P. De Beule, M. Casal, C. J. Stefan, G. Diallinas, S. Paiva

This study investigates the role of cytosolic termini in Jen1 transporter trafficking, activity, and endocytosis using yeast models.

bioRxiv · Sep 27, 2021 · PreprintMicrobiology

Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids

G. Talaia, J. Amick, S. Ferguson

This study identifies a peptide motif-mediated interaction between WDR41 and PQLC2 that regulates lysosomal complex recruitment in response to cationic amino acid availability.

bioRxiv · Jul 15, 2020Cell Biology

PQLC2 signals lysosomal cationic amino acid abundance to the C9orf72 complex

J. Amick, A. K. Tharkeshwar, G. Talaia, S. M. Ferguson

The paper identifies PQLC2 as a lysosomal cationic amino acid transporter that interacts with the C9orf72 complex and regulates its recruitment based on amino acid availability.

bioRxiv · Jun 13, 2019Cell Biology