S. M. Smith

HIV-1 controllers possess a unique CD8+ T-cell activation phenotype and loss of control is associated with increased expression of exhaustion markers

The paper examines CD8+ T-cell exhaustion in HIV-1 controllers and finds that loss of control correlates with increased exhaustion markers, which can be reversed by immune checkpoint blockade.

Integrative genomic analysis identifies unique immune environments associated with immunotherapy response in diffuse large B cell lymphoma

This study identifies unique immune environments in DLBCL associated with response to immunotherapy using an integrative multi-omic approach.

Single-cell transcriptomic analysis of pea shoot development and cell-type-specific responses to boron deficiency

This study uses single-cell RNA sequencing to analyze pea shoot development and cell-type-specific responses to boron deficiency, revealing differential gene expression and developmental impacts.

Functional traits of young seedlings predict trade-offs in seedling performance in three neotropical forests.

The paper shows that seedling functional traits and cotyledon strategy predict performance trade-offs across three tropical forests.

Reduced affinity of calcium sensing-receptor heterodimers and reduced mutant homodimer trafficking combine to impair function in a mouse model of Familial Hypocalciuric Hypercalcemia Type 1

This study investigates how CaSR mutations cause different disease outcomes by showing that heterodimers reduce WT affinity and rescue mutant trafficking, while homodimers fail to function.

Paired Associates Learning is Disrupted After Unilateral Parietal Lobe Controlled Cortical Impact in Rats: A Trial-by-Trial Behavioral Analysis

This study examines PAL performance in a rat TBI model, finding deficits in learning and an inflammatory microglial response in the thalamus.

The Forget-Me-Not dHCP study: 7 Tesla high resolution diffusion imaging in the unfixed post-mortem neonatal brain

The paper describes the Forget-Me-Not dHCP study, which acquires high-resolution diffusion MRI data from unfixed post-mortem neonatal brains and presents preliminary analyses of cortical and white matter structures.

Multi-modal adaptor-clathrin contacts drive coated vesicleassembly

This study identifies multi-modal adaptor-clathrin interactions essential for coated vesicle assembly, revealing two critical binding sites on AP2's β2 subunit.

Divergent receptor proteins confer responses to different karrikins in two ephemeral weeds

The paper shows that Brassica tournefortii uses different KAI2 homologues to respond to KAR1, while Arabidopsis thaliana prefers KAR2, with two amino acid variants explaining ligand selectivity.

Optimisation of a novel method for the production of single-span membrane proteins in Escherichia coli

This paper demonstrates a novel method to produce single-span membrane proteins in E. coli by blocking the export of a heterologous protein using the twin-arginine translocase.