C. Robinson

Overexpression of the receptor-like kinase BIR1 gene causes SOBIR1- and EDS1-dependent cell death phenotypes in Arabidopsis

This study shows that overexpression of BIR1 in Arabidopsis causes cell death and immune activation, dependent on EDS1 and SOBIR1, similar to BIR1 loss-of-function effects.

Pathology of naturally acquired high pathogenicity avian influenza virus H5N1 infection in seabirds

This study examines the pathological effects of HPAIV H5N1 in seabirds, finding increased tissue tropism and reproductive tract involvement in 2022 compared to 2021.

Comparison of Three Transcytotic Pathways for Distribution to Brain Metastases of Breast Cancer.

This study compares three transcytotic pathways for drug delivery to brain metastases of breast cancer and finds that albumin shows optimal distribution and uses a novel clathrin-independent endocytosis mechanism.

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.

The paper presents the crystal structure of SARS-CoV-2 nsp14 in apo-form and explains how nsp10 modulates its exonuclease activity through structural changes.

Semi-automated protocol to quantify and characterize fluorescent three-dimensional vascular images

The paper describes a semi-automated protocol to quantify and characterize 3D vascular images in mouse tissues, achieving 80% sensitivity and 90% specificity in automated segmentation.

A Single Multipurpose FSH-Blocking Therapeutic for Osteoporosis and Obesity

This paper develops and tests a first-in-class FSH-blocking antibody, MS-Hu6, showing efficacy in preventing obesity and osteoporosis in mice and safety in monkeys.

SARS-CoV-2 infection of circulating immune cells is not responsible for virus dissemination in severe COVID-19 patients

The paper investigates whether SARS-CoV-2 uses circulating immune cells to spread in severe COVID-19 patients and finds that these cells are not actively infected and not a source of viral dissemination.

Heavily burned wood from wildfires is less likely to provide functionality in streams

This study examines how burning level and season affect stream wood functions post-fire, finding heavily burned wood is less likely to provide substrate for aquatic biota.

Optimized pseudotyping conditions for the SARS-COV2 Spike glycoprotein

This paper optimizes conditions for generating SARS-CoV-2 Spike pseudotyped viral particles, achieving high titers and demonstrating their utility in detecting neutralizing antibodies in COVID-19 patient plasma.

Watered-down biodiversity? A comparison of metabarcoding results from DNA extracted from matched water and bulk tissue biomonitoring samples

The paper compares DNA metabarcoding results from water and bulk benthic samples, finding that water samples poorly represent taxa compared to bulk samples.

MmpL3 is a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine

This study identifies MmpL3 as a lipid transporter that binds trehalose monomycolate and phosphatidylethanolamine, providing insight into its role in mycobacterial cell wall biosynthesis.

Monitoring the eradication of the highly invasive topmouth gudgeon (Pseudorasbora parva) using a novel eDNA assay

The paper evaluates the effectiveness of a novel eDNA-qPCR assay in monitoring the eradication of topmouth gudgeon in treated ponds.

Optimisation of a novel method for the production of single-span membrane proteins in Escherichia coli

This paper demonstrates a novel method to produce single-span membrane proteins in E. coli by blocking the export of a heterologous protein using the twin-arginine translocase.

Simultaneous detection of invasive signal crayfish, endangered white-clawed crayfish and the crayfish plague pathogen using environmental DNA

The paper develops an eDNA HRM method to detect invasive and native crayfish species and their pathogen, providing rapid and sensitive monitoring for conservation.