Author

S. Meckelmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

D. White· 2 shared M. Aldrovandi· 2 shared P. Rodrigues· 2 shared R. Andrews· 2 shared V. Tyrrell· 2 shared A. Engler· 1 shared A. O'Connor· 1 shared C. Hinz· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

D. White

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2 papers

Recent·Most cited

Oxylipin metabolism is controlled by mitochondrial b-oxidation during bacterial inflammation.

M. Misheva, K. Kotzamanis, L. Davies, V. Tyrrell, P. Rodrigues, G. Benavides, H. Christine, R. Murphy, P. Kennedy, P. Taylor, M. Rosas, S. Jones, J. McLaren, S. Deshpande, R. Andrews, , V. O'Donnell

This study shows that mitochondrial β-oxidation removes oxylipins during bacterial inflammation, with CPT1 playing a key role, and identifies associated genetic upregulation in human sepsis.

bioRxiv · Aug 17, 2020Biochemistry

Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274

S. Meckelmann, J. Hawksworth, D. White, R. Andrews, P. Rodrigues, A. O'Connor, J. Alvarez Jarreta, V. Tyrrell, C. Hinz, Y. Zhou, J. Williams, M. Aldrovandi, W. J. Watkins, A. Engler, D. Slatter, , V. B. O'Donnell

The paper identifies metabolic dysregulation of lysophospholipid/autotaxin pathways linked to a CHD risk SNP, showing altered lipid metabolism and enzyme expression in multiple models.

bioRxiv · Oct 2, 2019Physiology