Author

J. Hawksworth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Assay:metabolomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. O'Connor· 2 shared J. Frayne· 2 shared P. Rodrigues· 2 shared S. Allen· 2 shared A. Engler· 1 shared A. M. Toye· 1 shared A. Price· 1 shared A. S. F. Oliveira· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

A. O'Connor

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Human cellular model systems of β-thalassemia enablein-depth analysis of disease phenotype

D. E. Daniels, I. Ferrer-Vicens, J. Hawksworth, T. N. Andrienko, E. M. Finnie, D. C. J. Ferguson, A. S. F. Oliveira, J.-Y. A. Szeto, M. C. Wilson, J. Frayne

This study creates human cellular models of β-thalassemia to analyze disease phenotype and develops an assay to assess treatment responses.

bioRxiv · Sep 1, 2022Cell Biology

LipidFinder 2.0: advanced informatics pipeline for lipidomics discovery applications

J. Alvarez-Jarreta, P. Rodrigues, E. Fahy, A. O'Connor, A. Price, C. Gaud, S. Andrews, P. Benton, G. Siuzdak, J. Hawksworth, M. Valdivia, S. Allen, V. O'Donnell

LipidFinder 2.0 improves lipidomics analysis with new modules for artefact filtering, isotope deletion, and FDR assessment, showing better performance than existing tools.

bioRxiv · Aug 16, 2020Biochemistry

Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274

S. Meckelmann, J. Hawksworth, D. White, R. Andrews, P. Rodrigues, A. O'Connor, J. Alvarez Jarreta, V. Tyrrell, C. Hinz, Y. Zhou, J. Williams, M. Aldrovandi, W. J. Watkins, A. Engler, D. Slatter, , V. B. O'Donnell

The paper identifies metabolic dysregulation of lysophospholipid/autotaxin pathways linked to a CHD risk SNP, showing altered lipid metabolism and enzyme expression in multiple models.

bioRxiv · Oct 2, 2019Physiology

Stable knockout and complementation of receptor expression using in vitro cell line derived reticulocytes for dissection of host malaria invasion requirements

T. J. Satchwell, K. E. Wright, K. L. Haydn-Smith, F. S.-R. Teran, J. Hawksworth, J. Frayne, A. M. Toye, J. Baum

This study uses reticulocytes from an immortalized erythroblast cell line to investigate host receptor roles in malaria invasion, showing basigin's essential function and cyclophilin B's non-requirement.

bioRxiv · Dec 13, 2018Cell Biology