Author

K. Cole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 3 Assay:whole-genome sequencing· 3 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2

Frequent Co-Authors

D. W. Eyre· 3 shared D. W. Crook· 2 shared N. D. Sanderson· 2 shared T. L. Street· 2 shared A. C. Resnick· 1 shared A. E. Baxter· 1 shared A. J. Brent· 1 shared A. Ledda· 1 shared

Activity by Year

2017-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersMicrobiology

D. W. Eyre

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Generative Adversarial Networks Accurately Reconstruct Pan-Cancer Histology from Pathologic, Genomic, and Radiographic Latent Features

F. M. Howard, H. Hieromnimon, S. Ramesh, J. Dolezal, S. Kochanny, Q. Zhang, B. Feiger, J. Peterson, C. Fan, C. Perou, J. M. Vickery, M. Sullivan, K. Cole, G. Khramtsova, A. T. Pearson

This paper introduces HistoXGAN, a GAN that reconstructs cancer histology from latent features, showing it retains tumor grade, histologic subtype, and gene expression patterns across 29 cancer types.

bioRxiv · Mar 22, 2024Cancer Biology

A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma

J. H. Sussman, D. A. Oldridge, W. Yu, C.-H. Chen, A. M. Zellmer, J. Rong, A. Parvaresh-Rizi, A. Thadi, J. Xu, S. Bandyopadhyay, Y. Sun, D. Wu, C. E. Hunter, S. Brosius, K. J. Ahn, , K. Tan

This study creates a longitudinal multiomic atlas of pediatric high-grade glioma, revealing distinct tumor cell states and therapeutic targets not seen in adult glioblastoma.

bioRxiv · Mar 6, 2024Cancer Biology

Hospital outbreak of carbapenem-resistant Enterobacteriales associated with an OXA-48 plasmid carried mostly by Escherichia coli ST399

A. Ledda, M. Cummins, L. P. Shaw, E. Jauneikaite, K. Cole, F. Lasalle, D. Barry, C. Rosmarin, S. Anaraki, D. Wareham, N. Stoesser, J. Paul, R. Manuel, B. Cherian, X. Didelot

The paper investigates a hospital outbreak of carbapenem-resistant Enterobacteriales, identifying an OXA-48 plasmid in E. coli ST399 as the main driver, with evidence of plasmid conjugation and clonal expansion.

bioRxiv · Jun 15, 2020Evolutionary Biology

Optimizing DNA extraction methods for Nanopore sequencing of Neisseria gonorrhoeae direct from urine samples

T. L. Street, L. Barker, N. D. Sanderson, J. Kavanagh, S. Hoosdally, K. Cole, R. Newnham, M. Selvaratnam, M. Andersson, M. Llewelyn, J. O'Grady, D. W. Crook, D. W. Eyre

This study optimizes DNA extraction methods for Nanopore sequencing of Neisseria gonorrhoeae directly from urine samples to enable culture-free whole-genome reconstruction.

Journal of Clinical Microbiology · Feb 24, 2020Peer-reviewedMicrobiology

RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates

S. G. Palace, Y. Wang, D. H. F. Rubin, M. Welsh, T. D. Mortimer, K. Cole, D. W. Eyre, S. G. Walker, Y. Grad

The paper identifies RNA polymerase mutations in Neisseria gonorrhoeae that confer ceftriaxone resistance independently of penA mutations.

bioRxiv · Aug 28, 2019Microbiology

Molecular diagnosis of orthopaedic device infection direct from sonication fluid by metagenomic sequencing

T. L. Street, N. D. Sanderson, B. L. Atkins, A. J. Brent, K. Cole, D. Foster, M. A. McNally, S. Oakley, L. Peto, A. Taylor, T. E. A. Peto, D. W. Crook, D. W. Eyre

This study shows metagenomic sequencing of sonication fluid can accurately diagnose prosthetic joint infections with high sensitivity and specificity.

bioRxiv · Mar 18, 2017Microbiology