Author

N. D. Sanderson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 9

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 7 Research Focus:variant calling· 5 Research Focus:differential expression· 4 Approach:experimental assay· 4 Assay:metagenomics· 4 Assay:long-read sequencing· 3 Approach:statistical model· 3 Approach:deep learning· 2

Frequent Co-Authors

D. W. Crook· 6 shared A. S. Walker· 4 shared D. Foster· 4 shared D. W. Eyre· 4 shared T. E. A. Peto· 4 shared T. L. Street· 4 shared D. Crook· 3 shared J. Kavanagh· 3 shared

Activity by Year

2017-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersMicrobiology

D. W. Crook

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Evaluation of the accuracy of bacterial genome reconstruction with Oxford Nanopore R10.4.1 long-read-only sequencing

N. D. Sanderson, K. Hopkins, M. Colpus, M. Parker, S. Lipworth, D. Crook, N. Stoesser

This paper evaluates the accuracy of bacterial genome reconstruction using Oxford Nanopore R10.4.1 long-read-only sequencing and finds it produces accurate assemblies at 40x depth, competitive with hybrid Illumina-Nanopore assemblies.

Microbial Genomics · May 7, 2024Peer-reviewedMicrobiology

DNA Thermo-Protection Facilitates Whole Genome Sequencing of Mycobacteria Direct from Clinical Samples by the Nanopore Platform

S. George, Y. Xu, G. Rodger, M. Morgan, N. D. Sanderson, S. Hoosdally, S. Thulborn, E. Robinson, P. Rathod, A. S. Walker, T. E. Peto, D. W. Crook, K. E. Dingle

This paper develops a thermo-protection buffer to enable direct whole genome sequencing of Mycobacteria from clinical samples using Nanopore technology, achieving high coverage at low bacterial concentrations.

bioRxiv · Apr 5, 2020 · PreprintMicrobiology

Optimizing DNA extraction methods for Nanopore sequencing of Neisseria gonorrhoeae direct from urine samples

T. L. Street, L. Barker, N. D. Sanderson, J. Kavanagh, S. Hoosdally, K. Cole, R. Newnham, M. Selvaratnam, M. Andersson, M. Llewelyn, J. O'Grady, D. W. Crook, D. W. Eyre

This study optimizes DNA extraction methods for Nanopore sequencing of Neisseria gonorrhoeae directly from urine samples to enable culture-free whole-genome reconstruction.

Journal of Clinical Microbiology · Feb 24, 2020Peer-reviewedMicrobiology

High precision Neisseria gonorrhoeae variant and antimicrobial resistance calling from metagenomic Nanopore sequencing

N. D. Sanderson, J. Swann, L. Barker, J. Kavanagh, S. Hoosdally, D. Crook, the GonFast Investigators Group, T. L. Street, D. W. Eyre

This study develops a workflow for high-precision variant and antimicrobial resistance calling from metagenomic Nanopore sequencing of Neisseria gonorrhoeae.

bioRxiv · Feb 7, 2020Microbiology

Metagenomic Nanopore sequencing of influenza virus direct from clinical respiratory samples

K. Lewandowski, Y. Xu, S. T. Pullan, D. Foster, N. D. Sanderson, A. Vaughan, M. Morgan, N. Bright, J. Kavanagh, R. T. Vipond, M. W. Carroll, A. C. Marriott, K. E. Gooch, M. Andersson, K. Jeffery, , P. C. Matthews

This study uses metagenomic Nanopore sequencing to detect influenza virus in clinical respiratory samples, achieving high sensitivity and complete genome sequencing.

bioRxiv · Jun 19, 2019Microbiology

Nanopore metagenomic sequencing of full length human metapneumovirus (HMPV) within a unique sub-lineage

Y. Xu, K. Lewandowski, S. Lumley, N. D. Sanderson, A. Vaughan, R. T. Vipond, M. W. Carroll, K. Jeffery, D. Foster, A. S. Walker, T. E. A. Peto, D. W. Crook, S. T. Pullan, P. C. Matthews

This study uses Nanopore metagenomic sequencing to directly sequence the full-length HMPV genome from a UK patient, identifying a unique genetic group and demonstrating the utility of Nanopore for clinical diagnosis.

bioRxiv · Dec 17, 2018 · PreprintMicrobiology

Control of artefactual variation in reported inter-sample relatedness during clinical use of a Mycobacterium tuberculosis sequencing pipeline

D. Wyllie, N. D. Sanderson, R. Myers, T. E. Peto, E. Robinson, D. W. Crook, G. Smith, A. S. Walker

The paper identifies genomic regions in Mycobacterium tuberculosis that contribute to artefactual variation in bacterial similarity searches and proposes a method to reduce such variation.

bioRxiv · Jan 23, 2018Microbiology

Real-time analysis of nanopore-based metagenomic sequencing from orthopaedic device infection

N. D. Sanderson, T. L. Street, D. Foster, J. Swann, B. L. Atkins, A. J. Brent, M. A. McNally, S. Oakley, A. Taylor, T. E. A. Peto, D. Crook, D. W. Eyre

This paper compares metagenomic sequencing using Illumina MiSeq and Oxford Nanopore MinION platforms for diagnosing prosthetic joint infections, demonstrating a real-time analysis pipeline for rapid bacterial detection.

bioRxiv · Nov 17, 2017Microbiology

Molecular diagnosis of orthopaedic device infection direct from sonication fluid by metagenomic sequencing

T. L. Street, N. D. Sanderson, B. L. Atkins, A. J. Brent, K. Cole, D. Foster, M. A. McNally, S. Oakley, L. Peto, A. Taylor, T. E. A. Peto, D. W. Crook, D. W. Eyre

This study shows metagenomic sequencing of sonication fluid can accurately diagnose prosthetic joint infections with high sensitivity and specificity.

bioRxiv · Mar 18, 2017Microbiology