A small-molecule myosin inhibitor as a targeted multi-stage antimalarial
D. V. Trivedi, A. Karabina, G. Bergnes, A. Racca, H. Wander, S. Jung, N. Mittal, T. Huijs, S. Ouchida, P. V. Ruijgrok, D. Song, S. Wittlin, P. Mukherjee, A. Chakraborty, E. A. Winzeler, , J. Spudich
This paper develops a small-molecule myosin inhibitor, KNX-115, effective against multiple stages of Plasmodium infection with high selectivity and potency.
bioRxiv · Sep 9, 2022 · PreprintPharmacology & Toxicology