N. Mittal

Improved prediction of stabilizing mutations in proteins by incorporation of mutational effects on ligand binding

The paper improves stabilizing mutation prediction by combining computational methods with experimental data, achieving higher precision and thermal stability increases.

Low Shear in Short-Term Impacts Endothelial Cell Traction and Alignment in Long-Term

This study examines how brief exposure to low shear stress affects endothelial cell traction and alignment over time, revealing lasting changes in cellular behavior.

Resident memory T cell precursors in tumor draining lymph nodes require type-1 IFN for optimal differentiation

Enhanced protective efficacy of a novel, thermostable, RBD-S2 fusion immunogen against SARS-CoV-2 and its variants

This study evaluates a novel RBD-S2 fusion immunogen that shows enhanced protection against SARS-CoV-2 and its variants in animal models.

A fast-killing tyrosine amide ((S)-SW228703) with blood and liver-stage antimalarial activity associated with the Cyclic Amine Resistance Locus (PfCARL)

This paper identifies (S)-SW228703, a tyrosine amide with fast-killing antimalarial activity against blood and liver stages of Plasmodium falciparum, and links resistance to mutations in PfCARL and PfACT.

A small-molecule myosin inhibitor as a targeted multi-stage antimalarial

This paper develops a small-molecule myosin inhibitor, KNX-115, effective against multiple stages of Plasmodium infection with high selectivity and potency.

A novel oral GyrB/ParE dual binding inhibitor effective against multidrug resistant Neisseria gonorrhoeae and other high-threat pathogens

The paper describes a novel oral inhibitor, JSF-2659, effective against multidrug-resistant Neisseria gonorrhoeae and other high-threat pathogens, with low potential for resistance development.

Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis

The paper reveals that mTORC1 promotes muscle atrophy by enhancing the ubiquitin-proteasome system through dual mechanisms, while also showing that proteome integrity depends on ubiquitination.

Nascent adhesions differentially regulate lamellipodium velocity and persistence

The paper develops a computational model to study how actin and adhesions regulate cell migration, finding that actin polymerization drives protrusion while adhesion lifetime affects velocity and persistence.

Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle

This study shows that calorie restriction and rapamycin have distinct and additive effects on aging skeletal muscle gene expression and function in mice.

A Small Molecule Fluorogenic Probe for the Detection of Sphingosine in Living Cells

This paper develops a fluorescent probe to detect sphingosine in living cells and demonstrates its use in detecting sphingosine accumulation in NPC1 patient cells.

Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box

The paper screens a compound library to identify antimalarial compounds active against multiple Plasmodium life stages and transmission-blocking agents.

Direct Arp2/3-vinculin binding is essential for cell spreading, but only on compliant substrates and in 3D

The paper investigates the role of actin-binding proteins in cell spreading on 2D and 3D substrates, finding that Arp2/3-vinculin binding is critical for 3D spreading but not 2D.

Local translation of yeast ERG4 mRNA at the endoplasmic reticulum requires the brefeldin A resistance protein Bfr1

This study shows Bfr1p binds ERG4 mRNA and facilitates its translation at the ER, while also playing a role in ploidy control and chromosome segregation.

Protein synthesis rates and ribosome occupancies reveal determinants of translation elongation rates

The paper infers translation initiation and elongation rates for yeast ORFs using ribosome footprinting and protein synthesis data, finding amino acid composition and codon/tRNA adaptation equally influence elongation rates.