J. Spudich

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy

This study shows that myosin inhibition with mavacamten is effective in treating HCM caused by both truncating and missense variants in MYBPC3, despite different pathomechanisms.

A small-molecule myosin inhibitor as a targeted multi-stage antimalarial

This paper develops a small-molecule myosin inhibitor, KNX-115, effective against multiple stages of Plasmodium infection with high selectivity and potency.

Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

This study examines how mutations in different regions of the β-cardiac myosin lever arm affect motor function and autoinhibition, revealing divergent effects based on mutation location.

A novel role for Myosin-Va in mitochondrial fission

This paper shows myosin-Va facilitates mitochondrial fission in melanoma cells by interacting with Spire1C and localizing to fission sites, linking it to the Warburg effect.

Crystal Structure of a Natural Light-Gated Anion Channelrhodopsin

This paper presents the X-ray structure of GtACR1, revealing a novel mechanism for anion conductance involving the Schiff base and tunnel architecture.

Controlling load-dependent contractility of the heart at the single molecule level

This study measures the load-dependent detachment rate of human β-cardiac myosin at the single molecule level and shows it can be modulated by compounds and mutations.