S. Viswanathan

Interleukin-11 causes alveolar type 2 cell dysfunction and prevents alveolar regeneration

This study shows IL11 impairs AT2 cell differentiation into AT1 cells and blocks lung regeneration in mice and humans.

Overturning the paradigm that IL6 signaling drives liver regrowth while shining light on a new therapeutic target for regenerative medicine

The paper challenges the role of IL6 in liver regeneration, showing HyperIL6 protects against liver damage and promotes regeneration independently of STAT3, highlighting IL11 as a new therapeutic target.

Redefining Interleukin 11 as a regeneration-limiting hepatotoxin

This study reveals IL11 as a hepatotoxin that limits liver regeneration after APAP overdose, showing its inhibition of endogenous IL11 activity protects mice.

Fibroblast-specific IL11 signaling is required for lung fibrosis and inflammation

This study shows that fibroblast-specific IL11 signaling is critical for lung fibrosis and that inflammation can result from stromal activation rather than being a primary driver.

Iron nanoparticle-labeled murine mesenchymal stromal cells in an osteoarthritic model persists and demonstrates anti-inflammatory mechanism of action

This study tracks iron nanoparticle-labeled MSCs in an OA model, showing they persist in joints and increase homeostatic macrophages, reducing inflammation.