Author

S. P. Spencer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Assay:metagenomics· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:database / resource· 1 Assay:proteomics· 1

Frequent Co-Authors

J. L. Sonnenburg· 3 shared M. R. Olm· 2 shared A. Bhattacharjee· 1 shared A. E. Overacre-Delgoffe· 1 shared A. H. P. Burr· 1 shared A. R. Jha· 1 shared B. D. Merrill· 1 shared B. R. Huckestein· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersMicrobiology

J. L. Sonnenburg

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Metagenomic Immunoglobulin Sequencing (MIG-Seq) Exposes Patterns of IgA Antibody Binding in the Healthy Human Gut Microbiome

M. R. Olm, S. P. Spencer, E. L. Silva, J. L. Sonnenburg

The paper introduces MIG-Seq to analyze IgA binding to gut microbiome strains and finds that microbial genes, especially mucus degradation genes, predict IgA binding levels.

bioRxiv · Nov 21, 2023 · PreprintMicrobiology

Fermented foods restructure gut microbiota and promote immune regulation via microbial metabolites

S. P. Spencer, E. G. Lemus Silva, E. Caffrey, R. N. Culver, R. H. Gellman, M. Wang, H. Wastyk, S. Higginbottom, J. L. Sonnenburg

This study shows fermented foods reshape gut microbiota and enhance immune regulation through microbial metabolites, independent of live microbes.

bioRxiv · May 11, 2022 · PreprintMicrobiology

Ultra-deep Sequencing of Hadza Hunter-Gatherers Recovers Vanishing Microbes

B. D. Merrill, M. M. Carter, M. R. Olm, D. Dahan, S. Tripathi, S. P. Spencer, F. B. Yu, S. Jain, N. Neff, A. R. Jha, E. D. Sonnenburg, J. L. Sonnenburg

The paper uses ultra-deep metagenomic sequencing to analyze the gut microbiome of Hadza hunter-gatherers, revealing many microbes absent from existing datasets and highlighting differences in microbial dynamics compared to industrialized populations.

bioRxiv · Mar 30, 2022 · PreprintMicrobiology

Enteropathy-induced regulatory T cells inhibit intestinal CD4+ T cell responses against oral vaccines

A. Bhattacharjee, A. H. P. Burr, A. E. Overacre-Delgoffe, J. T. Tometich, D. Yang, B. R. Huckestein, J. L. Linehan, S. P. Spencer, J. A. Hall, O. J. Harrison, D. Morais da Fonseca, E. B. Norton, Y. Belkaid, T. W. Hand

This study shows that EED-induced Tregs suppress intestinal CD4+ T cell responses to oral vaccines, but not lymph node responses, and worsen stunting when depleted.

bioRxiv · Jun 3, 2020 · PreprintImmunology