DNA methylation directs polycomb-dependent 3D genome re- organisation in naive pluripotency
K. A. McLaughlin, I. M. Flyamer, J. P. Thomson, H. K. Mjoseng, R. Shukla, I. Williamson, G. R. Grimes, R. S. Illingworth, I. R. Adams, S. Pennings, R. R. Meehan, W. A. Bickmore
This study shows that DNA hypomethylation in 2i conditions alters polycomb-mediated 3D genome organization in ESCs, but functional characteristics of 2i cells remain unchanged.
bioRxiv · Jan 22, 2019Cell Biology