Author

I. R. Adams

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:spatial domain detection· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

J. H. Crichton· 3 shared J. M. Dunce· 2 shared O. R. Davies· 2 shared G. R. Grimes· 1 shared H. K. Mjoseng· 1 shared I. M. Flyamer· 1 shared I. Williamson· 1 shared J. Lawson· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCell Biology

J. H. Crichton

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Author profile →

4 papers

Recent·Most cited

Computational Tools for the Analysis of Meiotic Prophase I Images

J. H. Crichton, I. R. Adams

The paper introduces computational tools for automated quantitative analysis of meiotic prophase I images, focusing on chromosome axis and recombination focus measurements.

bioRxiv · Nov 15, 2023 · PreprintCell Biology

Parallel recruitment pathways contribute to synaptonemal complex assembly during mammalian meiosis

J. H. Crichton, J. M. Dunce, W. M. Baarends, O. R. Davies, I. R. Adams

This study shows that SYCE2 is recruited to recombination sites early in SC assembly, independent of SYCP1, suggesting parallel recruitment pathways in mammalian meiosis.

bioRxiv · Apr 14, 2022 · PreprintCell Biology

Structural maturation of SYCP1-mediated meiotic chromosome synapsis through conformational remodelling by molecular adapter SYCE3

J. H. Crichton, J. M. Dunce, O. M. Dunne, L. J. Salmon, P. S. Devenney, J. Lawson, I. R. Adams, O. R. Davies

The paper reveals that SYCE3 remodels the SYCP1 lattice during meiotic synapsis, enabling long-range synapsis by forming an integrated SYCP1-SYCE3 lattice.

bioRxiv · Mar 6, 2022 · PreprintBiochemistry

DNA methylation directs polycomb-dependent 3D genome re- organisation in naive pluripotency

K. A. McLaughlin, I. M. Flyamer, J. P. Thomson, H. K. Mjoseng, R. Shukla, I. Williamson, G. R. Grimes, R. S. Illingworth, I. R. Adams, S. Pennings, R. R. Meehan, W. A. Bickmore

This study shows that DNA hypomethylation in 2i conditions alters polycomb-mediated 3D genome organization in ESCs, but functional characteristics of 2i cells remain unchanged.

bioRxiv · Jan 22, 2019Cell Biology