Author

J. P. Thomson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

G. R. Grimes· 2 shared A. Ewing· 1 shared A. Hamdan· 1 shared A. J. Drake· 1 shared A. Matakidou· 1 shared A. Meynert· 1 shared A. Thakker· 1 shared A. V. Biankin· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

G. R. Grimes

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Author profile →

3 papers

Recent·Most cited

Divergent trajectories to structural diversity impact patient survival in high grade serous ovarian cancer

A. Ewing, A. Meynert, R. Silk, S. Aitken, D. P. Bendixsen, M. Churchman, S. L. Brown, A. Hamdan, J. Mattocks, G. R. Grimes, T. Ballinger, R. L. Hollis, C. S. Herrington, J. P. Thomson, K. Sherwood, , C. A. Semple

The paper identifies two divergent structural variation trajectories in HGSOC that impact patient survival and reveals novel candidate driver genes and mtDNA mutations associated with prognosis.

bioRxiv · Jan 12, 2024Cancer Biology

Macrovesicular steatosis in nonalcoholic fatty liver disease is a consequence of purine nucleotide cycle driven fumarate accumulation

M. C. Sinton, B. Lucendo Villarin, J. Meseguer Ripolles, S. Wernig-Zorc, J. P. Thomson, P. D. Walker, A. Thakker, G. G. Lavery, C. Ludwig, D. A. Tennant, D. C. Hay, A. J. Drake

This study identifies fumarate accumulation driven by purine nucleotide cycle activity as a cause of macrovesicular steatosis in NAFLD using human pluripotent stem cell-derived hepatocytes.

bioRxiv · Jun 23, 2020Biochemistry

DNA methylation directs polycomb-dependent 3D genome re- organisation in naive pluripotency

K. A. McLaughlin, I. M. Flyamer, J. P. Thomson, H. K. Mjoseng, R. Shukla, I. Williamson, G. R. Grimes, R. S. Illingworth, I. R. Adams, S. Pennings, R. R. Meehan, W. A. Bickmore

This study shows that DNA hypomethylation in 2i conditions alters polycomb-mediated 3D genome organization in ESCs, but functional characteristics of 2i cells remain unchanged.

bioRxiv · Jan 22, 2019Cell Biology