Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19.
J. J. Clark, R. Penrice-Randal, P. Sharma, A. Kipar, X. Dong, S. Pennington, A. E. Marriott, S. Colombo, A. D. Davidson, M. Kavanagh Williamson, D. A. Matthews, L. Turtle, T. Prince, G. Hughes, E. I. Patterson, , J. P. Stewart
This study shows that sequential infection with influenza A virus followed by SARS-CoV-2 in mice leads to more severe disease and encephalitis compared to single infections.
bioRxiv · Oct 13, 2020 · PreprintMicrobiology