Author

E. I. Patterson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 12 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 13 Research Focus:host-pathogen & immune response· 11 Organism:human· 4 Organism:mouse· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1

Frequent Co-Authors

G. Hughes· 6 shared G. L. Hughes· 6 shared E. R. Anderson· 5 shared T. Prince· 5 shared A. Owen· 4 shared J. A. Hiscox· 4 shared J. P. Stewart· 4 shared A. Kipar· 3 shared

Activity by Year

2020-2022 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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6 shared papersMicrobiology

G. Hughes

Mutual co-authors in cluster

Author profile →

13 papers

Recent·Most cited

Vertical and horizontal transmission of cell fusing agent virus in Aedes aegypti

R. A. Logan, S. Quek, J. N. Muthoni, A. von Eicken, L. E. Brettell, E. R. Anderson, M. E. Villena, S. Hegde, G. T. Patterson, E. Heinz, G. L. Hughes, E. I. Patterson

This study investigates the transmission routes of CFAV in Aedes aegypti, finding vertical and paternal transmission rates and suggesting strategies for arbovirus control.

bioRxiv · May 26, 2022Microbiology

Virucidal activity of CPC-containing oral rinses against SARS-CoV-2 variants and are active in the presence of human saliva

E. R. Anderson, E. I. Patterson, S. Richards, A. K. Green, S. Mukherjee, M. Hoptroff, G. Hughes

This study evaluates CPC-containing mouthwashes' virucidal activity against SARS-CoV-2 variants, showing significant inactivation even in the presence of human saliva.

bioRxiv · Aug 5, 2021Microbiology

SARS-CoV-2 neutralising antibodies in Dogs and Cats in the United Kingdom

S. Smith, E. Anderson, C. Cansado Utrilla, T. Prince, S. Farrell, B. Brant, S. Smyth, P.-J. Noble, G. Pinchbeck, N. Marshall, L. Roberts, G. Hughes, A. Radford, E. I. Patterson

This study reports the first large-scale serological survey of SARS-CoV-2 neutralising antibodies in dogs and cats in the UK, finding low prevalence during the second wave of human infections.

bioRxiv · Jun 23, 2021Microbiology

Neuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mouse

F. Seehusen, J. J. Clark, P. Sharma, E. Bentley, A. Kirby, K. Subramaniam, S. Wunderlin Giuliani, G. Hughes, E. I. Patterson, B. D. Michael, A. Owen, J. A. Hiscox, J. P. Stewart, A. Kipar

This study investigates SARS-CoV-2 variant neuroinvasion in K18-hACE2 mice, finding CNS spread in all variants except Omicron, with microglial activation and immune cell apoptosis observed.

bioRxiv · Apr 16, 2021Pathology

Sequence analysis of SARS-CoV-2 in nasopharyngeal samples from patients with COVID-19 illustrates population variation and diverse phenotypes, placing the in vitro growth properties of B.1.1.7 and B.1.351 lineage viruses in context.

T. Prince, X. Dong, R. Penrice-Randal, N. Randle, C. Hartley, H. Goldswain, B. Jones, M. G. Semple, J. K. Baillie, P. J. M. Openshaw, L. Turtle, ISARIC4C Investigators, G. Hughes, E. Anderson, E. I. Patterson, , J. A. Hiscox

The paper analyzes SARS-CoV-2 sequence variation in patient samples and compares the in vitro growth of B.1.1.7 and B.1.351 variants to other isolates, finding no significant difference in growth for B.1.1.7.

bioRxiv · Mar 30, 2021 · PreprintMicrobiology

Naturally-acquired immunity in Syrian Golden Hamsters provides protection from re-exposure to emerging heterosubtypic SARS-CoV-2 variants B.1.1.7 and B.1.351

J. J. Clark, P. Sharma, E. Bentley, A. C. Harding, A. Kipar, M. Neary, H. Box, G. Hughes, E. I. Patterson, J. Sharp, T. de Oliveira, A. Sigal, J. A. Hiscox, W. S. James, M. W. Carroll, , J. P. Stewart

This study shows that prior SARS-CoV-2 infection in Syrian Golden Hamsters protects against re-exposure to variants B.1.1.7 and B.1.351, suggesting immunity may limit disease from emerging variants.

bioRxiv · Mar 10, 2021 · PreprintMicrobiology

Protein N-glycosylation is essential for SARS-CoV-2 infection

A. Casas-Sanchez, A. Romero-Ramirez, E. Hargreaves, C. C. Ellis, B. I. Grajeda, I. Estevao, E. I. Patterson, G. L. Hughes, I. C. Almeida, T. Zech, A. Acosta-Serrano

This study shows that host and viral N-glycosylation are essential for SARS-CoV-2 infection, with inhibition reducing infectivity and virion production.

bioRxiv · Feb 5, 2021 · PreprintMicrobiology

Remdesivir-Ivermectin combination displays synergistic interaction with improved in vitro antiviral activity against SARS-CoV-2

L. Jeffreys, S. H. Pennington, J. Duggan, C. H. Caygill, R. C. Lopeman, A. Breen, J. Jinks, A. Ardrey, S. Donnellan, E. I. Patterson, G. I. Hughes, W. D. Hong, P. M. O'Neill, G. Aljayyoussi, A. Owen, , G. A. Biagini

This study shows that combining remdesivir and ivermectin enhances antiviral activity against SARS-CoV-2 in vitro.

bioRxiv · Dec 23, 2020Microbiology

Inactivation of SARS-CoV-2 on surfaces and in solution with Virusend (TX-10), a novel disinfectant

E. R. Anderson, G. L. Hughes, E. I. Patterson

This study demonstrates that Virusend (TX-10) rapidly inactivates SARS-CoV-2 on surfaces and in solution, reducing viral titre by 4log10 PFU/mL within 1 minute.

bioRxiv · Nov 25, 2020Microbiology

Sequential infection with influenza A virus followed by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) leads to more severe disease and encephalitis in a mouse model of COVID-19.

J. J. Clark, R. Penrice-Randal, P. Sharma, A. Kipar, X. Dong, S. Pennington, A. E. Marriott, S. Colombo, A. D. Davidson, M. Kavanagh Williamson, D. A. Matthews, L. Turtle, T. Prince, G. Hughes, E. I. Patterson, , J. P. Stewart

This study shows that sequential infection with influenza A virus followed by SARS-CoV-2 in mice leads to more severe disease and encephalitis compared to single infections.

bioRxiv · Oct 13, 2020 · PreprintMicrobiology

Negeviruses reduce replication of alphaviruses during co-infection

E. I. Patterson, T. F. Kautz, M. A. Contreras-Gutierrez, H. Guzman, R. B. Tesh, G. L. Hughes, N. L. Forrester

This study shows negeviruses reduce replication of alphaviruses during co-infection and demonstrate a method to deliver anti-viral antibody fragments using paratransgenic ISVs.

bioRxiv · Sep 1, 2020Microbiology

Evidence of exposure to SARS-CoV-2 in cats and dogs from households in Italy

E. I. Patterson, G. Elia, A. Grassi, A. Giordano, C. Desario, M. Medardo, S. L. Smith, E. R. Anderson, T. Prince, G. T. Patterson, E. Lorusso, M. S. Lucente, G. Lanave, S. Lauzi, U. Bonfanti, , N. Decaro

The paper investigates SARS-CoV-2 exposure in companion animals in Italy, finding that 3.4% of dogs and 3.9% of cats had neutralizing antibodies, with higher prevalence in pets from households with COVID-19 cases.

bioRxiv · Jul 21, 2020 · PreprintMicrobiology

Methods of inactivation of SARS-CoV-2 for downstream biological assays

E. I. Patterson, T. Prince, E. R. Anderson, A. Casas-Sanchez, S. L. Smith, C. Cansado-Utrilla, L. Turtle, G. L. Hughes

This study tests methods to inactivate SARS-CoV-2 for use in lower containment laboratories, finding that heat, detergents, and UV light effectively inactivate the virus.

bioRxiv · May 21, 2020Microbiology