BioengineeringbioRxiv
Lipid nanoparticle topology regulates endosomal escape and delivery of RNA to the cytoplasm
L. Zheng, S. R. Bandara, C. Leal
This study shows that lipid nanoparticle (LNP) topology affects endosomal escape and RNA delivery efficiency, with bicontinuous cubic LNPs (cuboplexes) outperforming lamellar LNPs.
DOI 10.1073/pnas.2301067120