Author

S. R. Grossman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

A. M. Jecrois· 1 shared A. Y. Tan· 1 shared B. Ding· 1 shared B. E. Windle· 1 shared B. Hu· 1 shared B. Mishra· 1 shared C. A. Schiffer· 1 shared D. Bandyopadhyay· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperBiochemistry

A. M. Jecrois

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3 papers

Recent·Most cited

Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis

K. K. Chougoni, V. Neely, B. Ding, E. Oduah, V. Lam, B. Hu, J. E. Koblinski, B. E. Windle, S. P. Deb, S. Deb, S. K. Radhakrishnan, H. Harada, S. R. Grossman

This study shows proteasome inhibitors are more effective against NSCLC cells with mutant p53 by inducing oxidative stress and mitochondrial apoptosis, suggesting a new therapeutic strategy.

bioRxiv · Feb 22, 2024Cancer Biology

Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

T. Zhang, S. Li, A. Y. Tan, J. Na, Z. Chen, P. Damle, X. Chen, S. Choi, B. Mishra, D. Wang, S. R. Grossman, X. Jiang, Y. Li, Y.-T. Chen, J. Z. Xiang, N. Du

This study identifies CtBP2 as a mediator of Bcl-xL nuclear translocation, which promotes metastasis by enhancing H3K4me3 and TGFβ transcription.

bioRxiv · Apr 26, 2023Cancer Biology

CryoEM Structure of CtBP2 Confirms Tetrameric Architecture

A. M. Jecrois, M. M. Dcona, X. Deng, D. Bandyopadhyay, S. R. Grossman, C. A. Schiffer, W. E. Royer

The paper presents cryoEM structures of CtBP2 confirming its tetrameric architecture in the presence of NADH and shows that tetramer formation is essential for transcriptional activity and cell migration.

bioRxiv · Apr 6, 2020Biochemistry