Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis
K. K. Chougoni, V. Neely, B. Ding, E. Oduah, V. Lam, B. Hu, J. E. Koblinski, B. E. Windle, S. P. Deb, S. Deb, S. K. Radhakrishnan, H. Harada, S. R. Grossman
This study shows proteasome inhibitors are more effective against NSCLC cells with mutant p53 by inducing oxidative stress and mitochondrial apoptosis, suggesting a new therapeutic strategy.
bioRxiv · Feb 22, 2024Cancer Biology