B. Mishra

NK and NKT cells in the pathogenesis of Hidradenitis suppurativa: Novel therapeutic strategy through targeting of CD2

This study identifies expanded NKT and NK cells with elevated CD2 in HS lesions and shows CD2 blockade reduces inflammation and fibrosis.

Staphyloccocus aureus biofilm, in the absence of planktonic bacteria, produces factors that activate counterbalancing inflammatory and immune-suppressive genes in human monocytes

This study shows S. aureus biofilm produces soluble factors that activate inflammatory and immune-suppressive genes in human monocytes, suggesting a role for these factors in modulating immune responses in PJI.

The uniqueness of the Brazilian Yellow Fever Virus. Are the vaccines less effective against it?

The study identifies two unique amino acid substitutions in Brazilian YFV strains that may reduce vaccine effectiveness by altering epitope binding.

Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis

This study identifies CtBP2 as a mediator of Bcl-xL nuclear translocation, which promotes metastasis by enhancing H3K4me3 and TGFβ transcription.

Temporal control by co-factors prevents kinetic trapping in retroviral Gag lattice assembly

This study uses a reaction-diffusion model to show that co-factors like IP6 delay Gag lattice assembly, preventing kinetic trapping and enabling productive lattice formation.

CXCL4 signaling and gene induction in human monocytes

This study investigates CXCL4 signaling in human monocytes, identifying NF-κB and TBK1-JNK pathways and a potential role for TLR4, while noting challenges in isolating CXCL4's effects from endotoxin contamination.

Changes in m6A RNA methylation of goat lung following PPRV infection

This study investigates changes in m6A RNA methylation in goat lung tissue after PPRV infection, identifying altered m6A peaks and their association with immune-related pathways.

Phosphorylation dynamics in a flg22-induced, heterotrimeric G-protein dependent signaling network in Arabidopsis thaliana reveals a candidate PP2A phosphatase involved in AtRGS1 trafficking

Lotka-Volterra equations in the presence of Mimicry

The paper analyzes the dynamics of a multi-predator-multi-prey system with mimicry, focusing on stability and equilibrium in the context of viral evolution and vaccine stratification.

Efficient Agony Based Transfer Learning Algorithms for Survival Forecasting

This paper introduces a transfer learning algorithm using agony distance for improved survival forecasting in cancer progression modeling.

Speed limits of protein assembly with reversible membrane localization

The paper derives a model for protein assembly on membranes, showing how reduced dimensionality can significantly speed up complex formation.

Genomic basis of drought resistance in Fagus sylvatica

This study identifies genomic loci associated with drought resistance in European beech using Pool-GWAS, finding 106 SNPs linked to drought response genes and a predictive SNP-assay with 98.6% accuracy.

SARS-CoV-2 Spike Glycoprotein and ACE2 interaction reveals modulation of viral entry in wild and domestic animals

This study evaluates the interaction between SARS-CoV-2 spike protein and ACE2 receptors across species to predict viral entry probabilities in different animals.

Combinatorial library of biodegradable polyesters enables delivery of plasmid DNA to polarized human RPE monolayers for retinal gene therapy

The paper develops a high-throughput screening platform to identify biodegradable polymeric nanoparticles for efficient and safe delivery of plasmid DNA to human RPE cells.