Author

S. R. Jaffrey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:protein sequence· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

B. Wu· 1 shared D. Betel· 1 shared D. P. Patil· 1 shared E. Piskounova· 1 shared G. Cascio· 1 shared H. Liu· 1 shared I. Delclaux· 1 shared J. Gallon· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperBiochemistry

B. Wu

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Author profile →

3 papers

Recent·Most cited

Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis

L. A. Nease, K. P. Church, I. Delclaux, S. Murakami, M. A. Amiama, M. Zerhouni, G. Cascio, R. O. Hughes, P. Zumbo, L. E. Dow, S. R. Jaffrey, D. Betel, E. Piskounova

This study shows that FTSJ1-mediated tRNASec methylation enhances oxidative stress resistance and metastatic colonization in melanoma.

bioRxiv · Oct 2, 2023Cancer Biology

Mapping of m6A and Its Regulatory Targets in Prostate Cancer Reveals a METTL3-low Induction of Therapy Resistance

K. A. Cotter, J. Gallon, N. Uebersax, P. Rubin, K. D. Meyer, S. Piscuoglio, S. R. Jaffrey, M. A. Rubin

The paper maps m6A in prostate cancer and shows METTL3-low promotes therapy resistance through upregulated extracellular matrix proteins and hepatocyte nuclear factor-driven gene signatures.

bioRxiv · Jan 12, 2021Cancer Biology

Molecular Basis For The Specific And Multivariate Recognitions Of RNA Substrates By Human hnRNPA2/B1

B. Wu, S. Su, D. P. Patil, H. Liu, J. Gan, S. R. Jaffrey, J. Ma

This study determines the crystal structures of hnRNPA2/B1's RRM domains bound to RNA substrates, revealing sequence-specific recognition and suggesting a matchmaker mechanism, but not m6A binding.

bioRxiv · Jun 1, 2017Biochemistry