D. Betel

CAR-engineered lymphocyte persistence is governed by a FAS ligand/FAS auto-regulatory circuit

This study identifies FASLG expression patterns and shows that FAS-L/FAS auto-regulation governs CAR-T and CAR-NK cell persistence, enhancing antitumor efficacy when FAS is inhibited.

Selenocysteine tRNA methylation promotes oxidative stress resistance in melanoma metastasis

This study shows that FTSJ1-mediated tRNASec methylation enhances oxidative stress resistance and metastatic colonization in melanoma.

Identifying novel age-modulating compounds and quantifying cellular aging using novel computational framework for evaluating transcriptional age

The paper introduces RNAge, a transcriptional age score, to quantify cellular aging and identify age-modulating compounds in hPSC-derived cells.

Intratumoral immune triads are required for adoptive T cell therapy-mediated elimination of solid tumors

This study identifies intratumoral CD4 T cell::CD8 T cell::APC triads as essential for effective adoptive T cell therapy and anti-tumor immunity in both preclinical models and human lung cancer patients.

Cross-species single-cell comparison of systemic and cardiac inflammatory responses after cardiac injury

This study compares systemic and cardiac inflammatory responses to injury in mice and zebrafish using single-cell transcriptomics, revealing distinct monocyte/macrophage transcriptional clusters and divergent responses between species.

An epigenetic memory of inflammation controls context-dependent lineage plasticity in the pancreas

This study shows that inflammation leaves an epigenetic memory in pancreatic acinar cells, affecting their lineage plasticity and tumorigenesis in response to subsequent stress.

Immunogenicity of a public neoantigen derived from mutated PIK3CA

The paper investigates the immunogenicity of a public neoantigen derived from mutated PIK3CA, showing it is recognized by T cells and presents a framework for immunotherapy.

Selective BCL-XLAntagonists Eliminate Infected Cells from a Primary Cell Model of HIV Latency but not from Ex Vivo Reservoirs

This study shows BCL-XL antagonists reduce HIV in a cell model of latency but not in ex vivo reservoirs, suggesting resistance in true reservoir cells.

Unacylated ghrelin and AZP531 suppress the 3D growth of breast cancers

This study shows unacylated ghrelin and its analog AZP531 inhibit breast cancer growth in 3D cultures and xenografts by suppressing MAPK signaling and inducing apoptosis.