K. M. Trybus

Spatial Relationships Matter: Kinesin-1 Molecular Motors Transport Liposome Cargo Through 3D Microtubule Intersections In Vitro

This paper studies how kinesin-1 motors transport liposome cargo through 2D and 3D microtubule intersections, finding that spatial relationships bias directional outcomes, with a higher straight-through rate at 3D intersections.

Acetylation of fission yeast tropomyosin does not promote differential association with cognate formins

This study investigates whether acetylation of fission yeast tropomyosin affects its binding to formins, finding no preferential association with formin-mediated actin filaments.

Coil-to-Helix Transition at the Nup358-BicD2 Interface Activates BicD2 for Dynein Recruitment

The paper identifies a Nup358 helix that transitions to an α-helix upon BicD2 binding, facilitating dynein recruitment and processive motility.

Individual Molecular Motors use Low Forces to bypass Roadblocks during Collective Cargo Transport

The paper measures forces exerted by individual kinesin motors during cargo transport, finding they exert less than a piconewton even when bypassing obstacles.

Structure of Full Length Plasmodium Myosin A and its light chain PfELC, dual targets against malaria parasite pathogenesis

The paper presents the full-length structure of Plasmodium falciparum Myosin A (PfMyoA) and its light chain PfELC, revealing interactions critical for motor function and identifying PfELC as a potential antimalarial target.

Coiled-coil registry shifts in the F684I mutant of Bicaudal result in cargo-independent activation of dynein motility

The paper shows that a coiled-coil registry shift in the F684I mutant of BicD activates dynein motility without cargo, and suggests this mechanism may modulate cargo selection in BicD2.

Multiple Kinesins Induce Tension for Smooth Cargo Transport

The paper shows that small groups of kinesins use asymmetric tension and cooperation to move cargo efficiently in crowded cells.

MAP7 recruits kinesin-1 to microtubules to direct organelle transport

This study shows that MAP7 recruits kinesin-1 to microtubules, enhancing plus-end-directed organelle transport by increasing kinesin binding and motor engagement.

MYOSIN VA TRANSPORT OF LIPOSOMES IN THREE-DIMENSIONAL ACTIN NETWORKS IS MODULATED BY ACTIN FILAMENT DENSITY, POSITION, AND POLARITY

This study investigates how actin filament density, position, and polarity affect MyoVa-mediated liposome transport in 3D actin networks using in vitro models and computational simulations.

Recruitment of Two Dyneins to an mRNA-Dependent Bicaudal D Transport Complex

The paper shows that full-length BicD requires both Egl and mRNA to activate dynein-dynactin motility for mRNA transport, recruiting two dyneins to enhance transport efficiency.

Small teams of myosin Vc coordinate their stepping for efficient cargo transport on actin bundles

This study compares the stepping behavior of myosin Vc teams and myosin Va, showing that myoVc teams move more efficiently on actin bundles due to coordinated stepping.