Author

G. E. Ward

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 7

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Assay:electronic health records· 1 Organism:mouse· 1

Frequent Co-Authors

R. V. Stadler· 3 shared A. K. Snyder· 2 shared D. M. Warshaw· 2 shared N. J. Westwood· 2 shared P. K. Rompikuntal· 2 shared A. Heaslip· 1 shared A. Hunt· 1 shared A. Kelsen· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersMicrobiology

R. V. Stadler

Mutual co-authors in cluster

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7 papers

Recent·Most cited

The Toxoplasma subpellicular network is highly interconnected and defines parasite shape for efficient motility and replication

P. S. Back, V. Senthilkumar, C. P. Choi, A. M. Ly, A. K. Snyder, J. G. Lau, G. E. Ward, P. J. Bradley

This study identifies the role of TgIMC6 in Toxoplasma's subpellicular network, showing its importance in parasite shape and function through protein interactions and morphological analysis.

bioRxiv · Aug 10, 2023 · PreprintMicrobiology

The class XIV myosin of Toxoplasma gondii, TgMyoA, is druggable in an animal model of infection

A. Kelsen, R. S. Kent, A. K. Snyder, E. Wehri, S. J. Bishop, R. V. Stadler, C. Powell, B. Martorelli di Genova, P. K. Rompikuntal, M. J. Boulanger, D. M. Warshaw, N. J. Westwood, J. Schaletzky, G. E. Ward

This paper identifies KNX-002 as a specific inhibitor of TgMyoA, reducing parasite motility and disease progression in mice.

bioRxiv · Sep 9, 2022 · PreprintMicrobiology

CDPK2A and CDPK1 form a signaling module upstream of Toxoplasma motility

E. Shortt, C. G. Hackett, R. V. Stadler, G. E. WARD, S. Lourido

This paper identifies CDPK2A and CDPK1 as a signaling module regulating Toxoplasma motility, showing their functional interaction and role in microneme discharge and egress.

bioRxiv · Jul 19, 2022 · PreprintMicrobiology

A circular zone of attachment to the extracellular matrix provides directionality to the motility of Toxoplasma gondii in 3D

R. V. Stadler, S. R. Nelson, D. M. Warshaw, G. E. Ward

This study uses 3D traction force mapping to show that Toxoplasma gondii generates inward-directed forces at a circular zone of attachment to the extracellular matrix, providing directionality to its motility.

bioRxiv · Jun 8, 2022Microbiology

The potent Toxoplasma gondii growth inhibitor QQ-437 does not bind to its predicted target, parasite adaptin3β, in yeast three-hybrid assays

F. Tran, J. E. Foderaro, N. J. Westwood, G. E. Ward

The paper tests if QQ-437 inhibits Toxoplasma gondii growth by binding to TgAP3β, but finds no direct binding in yeast three-hybrid assays.

bioRxiv · Jun 7, 2022 · PreprintMicrobiology

Blocking palmitoylation of Toxoplasma gondii myosin light chain 1 disrupts glideosome composition but has little impact on parasite motility

P. K. Rompikuntal, I. T. Foe, B. Deng, M. Bogyo, G. E. WARD

This study shows that blocking palmitoylation of T. gondii TgMLC1 disrupts its association with TgGAP45 but does not significantly affect parasite motility.

bioRxiv · Aug 13, 2020Microbiology

Differential requirements of cyclase associated protein (CAP) for actin turnover during the lytic cycle of Toxoplasma gondii

A. Hunt, J. Wagener, R. Kent, R. Carmeille, M. Russell, C. Peddie, L. Collinson, A. Heaslip, G. E. Ward, M. Treeck

This study investigates the role of cyclase-associated protein (CAP) in actin turnover during the Toxoplasma gondii lytic cycle, finding differential requirements for CAP in cell-cell communication and residual body formation.

bioRxiv · Mar 6, 2019 · PreprintMicrobiology