SETD2 safeguards the genome against isochromosome formation
F. Mason, E. S. Kounlavong, A. T. Tebeje, R. Dahiya, T. Guess, L. Vlach, S. R. Norris, C. A. Lovejoy, R. Dere, R. Ohi, P. Ly, C. L. Walker, W. K. Rathmell
This study shows that SETD2 loss leads to chromosome segregation errors and DNA bridging via isochromosome formation, contributing to genomic instability in cancer.
bioRxiv · Oct 25, 2022 · PreprintCancer Biology