W. K. Rathmell

Metabolite profiling of human renal cell carcinoma reveals tissue-origin dominance in nutrient availability

This study profiles metabolites in renal cell carcinoma tissue and fluid to show that nutrient availability is more influenced by tissue-specific factors than tumor-driven changes.

Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation

The paper shows that fever increases inflammatory activity in CD4+ T cells but causes mitochondrial dysfunction and DNA damage specifically in Th1 cells, leading to p53-dependent apoptosis to prevent mutations.

PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity

This study shows obesity induces PD-1 on tumor-associated macrophages, which suppresses anti-tumor immunity by altering metabolic and functional properties of these cells.

SETD2 safeguards the genome against isochromosome formation

This study shows that SETD2 loss leads to chromosome segregation errors and DNA bridging via isochromosome formation, contributing to genomic instability in cancer.

ACSS2 Regulates HIF-2α Degradation through the E3-Ubiquitin Ligase MUL1 in Clear Cell Renal Cell Carcinoma

This study shows ACSS2 promotes HIF-2 stability by preventing its interaction with MUL1, and inhibiting ACSS2 reduces HIF-2 levels and suppresses ccRCC growth.

A Family of Glycosylated Macrolides Selectively Target Energetic Vulnerabilities in Leukemia

This study identifies the mitochondrial ATP synthase as the target of apoptolidin family glycomacrolides and demonstrates their efficacy in suppressing leukemia progression.

Multiplatform Computational Analysis of Mast Cells in Adrenocortical Carcinoma Tumor Microenvironment

The paper uses computational analysis to identify mast cell signatures in ACC tumor microenvironment, finding anti-tumor associations with improved survival.

Multiplatform Integrative Analyses of Immunosuppressive Signatures in Cortisol-secreting Adrenocortical Carcinoma

This study identifies immunosuppressive signatures in cortisol-secreting adrenocortical carcinoma (CS-ACC) through multiplatform immunogenomic analyses, linking these signatures to poor prognosis and immunotherapy resistance.

SETD2 regulates the methylation of translation elongation factor eEF1A1 in clear cell renal cell carcinoma

The paper investigates how SETD2 mutations in clear cell renal cell carcinoma affect protein methylation and translation, finding dysregulated translation linked to poor patient outcomes.

Molecular determinants for α-tubulin methylation by SETD2

This study identifies the molecular mechanisms by which SETD2 methylates α-tubulin, revealing distinct substrate recognition and catalytic requirements for tubulin versus histone methylation.

Cell Programmed Nutrient Partitioning in the Tumor Microenvironment

The paper measures nutrient uptake in the tumor microenvironment using PET tracers and finds cancer cells prefer glutamine while myeloid cells consume most glucose.

SETD2 is an actin lysine methyltransferase

This study identifies SETD2 as an actin lysine methyltransferase that regulates actin polymerization and cell migration through methylation of the actin cytoskeleton.