The structure of Macrophage Expressed Gene-1, a phagolysosome immune effector that is activated upon acidification.
S. S. Pang, C. Bayly-Jones, M. Radjainia, B. A. Spicer, R. H. P. Law, A. W. Hodel, S. M. Ekkel, P. J. Conroy, G. Ramm, H. Venugopal, P. I. Bird, B. W. Hoogenboom, I. Voskoboinik, Y. Gambin, E. Sierecki, , J. C. Whisstock
This paper determines the structure of MPEG-1, showing it forms a pre-pore complex and can perforate membranes under acidic conditions.
bioRxiv · Mar 17, 2019 · PreprintBiochemistry