Author

P. I. Bird

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Immunology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Ramirez· 1 shared A. Suhrbier· 1 shared A. W. Hodel· 1 shared B. A. Spicer· 1 shared B. W. Hoogenboom· 1 shared C. Bayly-Jones· 1 shared C. Bishop· 1 shared D. J. Rawle· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperImmunology

A. Ramirez

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Author profile →

4 papers

Recent·Most cited

An inconvenient association between granzyme A and Nicotinamide Nucleotide Transhydrogenase

D. J. Rawle, T. Le, T. Dumenil, C. Bishop, K. Yan, E. Nakayama, P. I. Bird, A. Suhrbier

The paper identifies an association between granzyme A and Nicotinamide Nucleotide Transhydrogenase in mice, showing that Nnt, not GzmA loss, affects disease outcomes and highlights inconsistencies in Nnt sequencing data.

bioRxiv · Mar 16, 2021Immunology

Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis.

M. Arias, J. Pardo, M. Garzon, J. L. Sierra, L. Comas, L. Santiago, T. Khaliulina, I. Uranga, A. Ramirez, E. Tapia, E. Morte, S. Algarate, L. Couty, E. Camerer, P. I. Bird, , E. Galvez

This study shows that inhibiting Granzyme A reduces inflammation and improves survival in abdominal sepsis by decreasing proinflammatory markers without affecting bacterial load.

bioRxiv · Jun 5, 2020Immunology

Detection of active Granzyme A in NK92 cells with fluorescent activity-based probe

S. Kolt, T. Janiszewski, D. Kaiserman, S. Modrzycka, S. S. Snipas, G. Salvesen, M. Drag, P. I. Bird, P. Kasperkiewicz

The paper develops a fluorescent activity-based probe to detect and track Granzyme A activity in NK92 cells.

bioRxiv · Dec 10, 2019Biochemistry

The structure of Macrophage Expressed Gene-1, a phagolysosome immune effector that is activated upon acidification.

S. S. Pang, C. Bayly-Jones, M. Radjainia, B. A. Spicer, R. H. P. Law, A. W. Hodel, S. M. Ekkel, P. J. Conroy, G. Ramm, H. Venugopal, P. I. Bird, B. W. Hoogenboom, I. Voskoboinik, Y. Gambin, E. Sierecki, , J. C. Whisstock

This paper determines the structure of MPEG-1, showing it forms a pre-pore complex and can perforate membranes under acidic conditions.

bioRxiv · Mar 17, 2019 · PreprintBiochemistry