S. Sadegh-Nasseri

H2-O deficiency promotes regulatory T cell differentiation and CD4 T cell hyperactivity

This study shows H2-O deficiency enhances thymic Treg development and increases peripheral Treg frequency, along with activated CD4 T cells.

Commensal Bacteria Maintain a Qa-1b-restricted Unconventional CD8+ T Population in Gut Epithelium

The paper identifies Qa-1b-restricted CD8+ T cells in the gut epithelium, showing they depend on commensal bacteria for maintenance.

Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes

This study shows that Fam49b suppresses TCR signaling to prevent excessive negative selection in thymocytes, ensuring normal T cell development.