N. Song

Microbiota from young mice counteracts susceptibility to age-related gout through modulating butyric acid levels in aged mice

This study shows that microbiota from young mice reduces age-related gout susceptibility by increasing butyric acid and modulating uric acid metabolism in aged mice.

Blockade of TREM2 ameliorates pulmonary inflammation and fibrosis by modulating sphingolipid metabolism

This study shows that blocking TREM2 reduces pulmonary inflammation and fibrosis by altering sphingolipid metabolism and chemokine expression in macrophages.

The integrated stress response/eIF2α pathway controls cytokine production in tissue-resident memory CD4+ T cells

This study shows that the ISR/eIF2α pathway regulates cytokine mRNA translation in Trm cells, limiting their activity in homeostasis but enabling rapid response during inflammation or autoimmunity.

H2-O deficiency promotes regulatory T cell differentiation and CD4 T cell hyperactivity

This study shows H2-O deficiency enhances thymic Treg development and increases peripheral Treg frequency, along with activated CD4 T cells.

The first complete mitochondrial genome of Sphaeniscus atilius (Walker, 1849) (Diptera: Tephritidae) and implications for the phylogenetic relationships of Tephritidae

This study characterizes the first complete mitochondrial genome of Sphaeniscus atilius and presents phylogenetic insights for Tephritidae family relationships.

Emergence and suppressive function of Tr1 cells in glomerulonephritis

This study identifies Tr1 cells in glomerulonephritis, showing their suppressive function and potential as therapeutic targets.

Integrates JA and ethylene signals in defense against brown spot disease: the role of NaWRKY70

The paper identifies NaWRKY70 as a key regulator integrating jasmonate and ethylene signals to synergistically induce phytoalexin biosynthesis in response to Alternaria alternata.

GM-CSF drives immune-mediated glomerular disease by licensing monocyte-derived cells to produce MMP12

The paper identifies GM-CSF-producing T cells that drive glomerulonephritis by licensing monocyte-derived cells to produce MMP12, leading to renal tissue damage.

Multiple expression assessments of ACE2 and TMPRSS2 SARS-CoV-2 entry molecules in the urinary tract and their associations with clinical manifestations of COVID-19

The YdiU Domain Modulates Bacterial Stress Signaling through Mn2+-dependent UMPylation

This paper identifies YdiU as a Mn2+-dependent UMPylase in Salmonella that modulates chaperone function through UMPylation, enhancing stress resistance.

LonP1 Orchestrates UPRmt and UPRER and Mitochondrial Dynamics to Regulate Heart Function

This study shows LonP1 regulates UPRmt and UPRER, and mitochondrial dynamics in cardiomyocytes, impacting heart function and revealing potential therapeutic targets for heart failure.

Large-scale chemical-genetics yields new Mycobacterium tuberculosis inhibitor classes

This study uses a novel chemical-genetics screening strategy to identify new inhibitors of Mycobacterium tuberculosis, revealing novel compound classes targeting previously unexplored bacterial targets.