L. Coscoy

SARS-CoV-2 Envelope-mediated Golgi pH dysregulation interferes with ERAAP retention in cells

This study identifies SARS-CoV-2 Envelope protein-induced Golgi pH neutralization as a mechanism causing ERAAP loss and extracellular release, highlighting ERAAP as a sensor of secretory pathway disturbances during infection.

The promiscuous development of an unconventional Qa1b-restricted T cell population

The paper identifies a CD8 T cell population, QFL T cells, restricted to MHC-E that develops independently of classical MHC I and requires Qa1b for agonist selection and functionality.

Murine cytomegalovirus downregulates ERAAP and induces an unconventional T cell response to self

This study shows that MCMV downregulates ERAAP, leading to self-peptide presentation and an unconventional T cell response that reduces viral load.

Fam49b dampens TCR signal strength to regulate survival of positively selected thymocytes

This study shows that Fam49b suppresses TCR signaling to prevent excessive negative selection in thymocytes, ensuring normal T cell development.

Comparative analysis of macrophage post-translational modifications during intracellular bacterial pathogen infection

This study uses proteomics to analyze post-translational modifications in macrophages infected with three intracellular pathogens, revealing pathogen-specific molecular responses and a novel mechanism of virus-bacterial synergy.

Heparan sulfate expression on B cells modulates IgM expression in aged mice and steady-state plasma cells

This study shows that B cell heparan sulfate expression affects IgM levels in aged mice but not overall B cell function or response to infection.

A Kaposi’s Sarcoma-Associated Herpesvirus Infection Mechanism is Independent of Integrins α3β1, αVβ3, and αVβ5

This study identifies an integrin-independent KSHV infection mechanism requiring HS and EphA2 but not Vβ1-family integrins or EphA2 intracellular domain.